国际医药卫生导报2019，Vol.25Issue(9)：1420-1423,4.DOI:10.3760/cma.j.issn.1007-1245.2019.09.019
螺内酯联合缬沙坦对高血压早期肾损害患者尿微量白蛋白及肾功能的影响
Effects of spironolactone combined with valsartan on microalbuminuria and renal function in patients with early renal damage caused by hypertension
管红斌 1何凯平 2桓文穆1
作者信息
- 1. 广东药科大学附属第一医院肾内科,广州 510080
- 2. 广东药科大学附属第一医院病案统计科,广州510080
- 折叠
摘要
Abstract
Objective To explore the clinical efficacy and safety of an spironolactone combined with valsartan in the treatment of patients with early renal damage caused by hypertension.Methods Sixty patients with early renal damage caused by hypertension were randomly divided into a control group and a treatment group.The control group took valsartan 80 mg/d in the morning,and the dosage was increased to 160 mg/d within 2 weeks;in addition,the treatment group took spironolactone 20 mg/d for 12 weeks.The microalbuminuria (MAU),urine beta2-microglobulin (β2-MG),serum cystatin C (CysC),serum potassium(K) were determined before and after the treatment.Results After the treatment,the levels of MAU,β2-MG,and CysC were significantly lower in the treatment group than in the control group [(38.52±3.65) mg/L vs.(69.86±0.65) mg/L,(2.33±0.19) mg/L vs.(4.93±0.26) mg/L,and (0.62±0.01) mg/L vs.(0.86±0.03) mg/L;all P ＜ 0.05].The level of K was (4.11±0.42) mmol/L in the treatment group and was (3.93±0.52) mmol/L in the control group (P ＞ 0.05).Conclusion Spironolactone combined with valsartan for patients with early renal damage caused by hypertension can lower the levels of MAU and β2-MG,and improve the renal function.关键词
螺内酯/缬沙坦/高血压病/尿微量白蛋白/尿β2-微球蛋白/血清胱抑素Key words
Spironolactone/Valsartan/Hypertension/Microalbuminuria/Urine β2-microglobulin/Serum cystatin C引用本文复制引用
管红斌,何凯平,桓文穆..螺内酯联合缬沙坦对高血压早期肾损害患者尿微量白蛋白及肾功能的影响[J].国际医药卫生导报,2019,25(9):1420-1423,4.
