国际医药卫生导报2019，Vol.25Issue(9)：1449-1453,5.DOI:10.3760/cma.j.issn.1007-1245.2019.09.028
利伐沙班联合阿替普酶在急性肺栓塞急诊治疗中的应用及对患者炎性因子水平的影响
Rivaroxaban combined with alteplase in emergency treatment of patients with acute pulmonary thromboembolism and its effect on levels of inflammatory factors
高超 1张华 1李红建2
作者信息
- 1. 山东省单县中心医院急诊科 274300
- 2. 山东省单县中心医院呼吸内科 274300
- 折叠
摘要
Abstract
Objective To investigate the application of rivaroxaban and alteplase in the emergency treatment of patients with acute pulmonary thromboembolism (APTE) and its effect on the levels of inflammatory factors.Methods Eighty patients with APTE admitted to the emergency department of our hospital from June 2015 to June 2018 were enrolled,and were divided into an observation group and a control group using a random number method.All the patients was given basic treatment to maintain vital signs;and the control group was treated with warfarin and alteplase,and the observation group with rivaroxaban and alteplase.48 hours after the treatment,the patients' arterial blood was collected for blood gas analysis;three-dimensional echocardiography was performed to examine the proximal pulmonary artery or right heart cavity thrombosis;and the right heart function was evaluated.The clinical efficacy was determined after 7 days' treatment.The adverse reactions of the two groups during the treatment were observed and recorded.Results The total effective rate was 90.00％ in the observation group,and was 72.50％ in the control group (P ＜ 0.05).48 h after the treatment,the PaO2,PaCO2,and RVEF were increased and the P(Aa)O2,RVESVI,and RVEDVI as well as the levels of TNF-α,IL-10 and CRP were decreased in both groups,and were better in the observation group than in the control group (all P ＜ 0.05).The incidence of major bleeding events in the observation group was significantly lower than that in the control group(P ＜ 0.05).Conclusions Rivaroxaban combined with alteplase in the treatment of APTE has a good clinical effect and an advantage in preventing major bleeding,and can reduce the levels of serum inflammatory factors and improve cardiopulmonary function.关键词
利伐沙班/阿替普酶/急性肺栓塞/临床疗效/炎症因子Key words
Rivaroxaban/Alteplase/Acute pulmonary thromboembolism/Clinical efficacy/Inflammatory factors引用本文复制引用
高超,张华,李红建..利伐沙班联合阿替普酶在急性肺栓塞急诊治疗中的应用及对患者炎性因子水平的影响[J].国际医药卫生导报,2019,25(9):1449-1453,5.
