摘要
Abstract
Objective To investigate the clinical value of the ratios of amino-terminal B type natriuretic peptide (NT-proBNP) to SCr and SCysC in the diagnosis of chronic renal failure complicated with heart failure.Methods 36 patients without chronic renal failure (CRF) or chronic heart failure (CHF),50 with CRF,43 with CHF,and 38 with CRF complicated with CHF were randomly selected from Guangdong Second People's Hospital from August,2016 to November,2018.We measured SCr,SCysC,and NT-proBNP in all the subjects,and calculated NT-proBNP/SCr,NT-proBNP/SCysC,eGFR.All the data were analyzed and compared.Results NT-proBNP significantly,independently,and positively correlated with SCr and SCysC (P ＜ 0.05).Kruskal-Wallis H test of NT-proBNP,NT-proBNP/SCr,and NT-proBNP/SCysC in the 4 groups showed that there were statistical differences in NT-proBNP,NT-proBNP/SCr,and NT-proBNP/SCysC among the four groups (P ＜ 0.05).The rank sum test of NT-proBNP,NT-proBNP/SCr,and NT-proBNP/SCysC pairwise comparisons in the four groups showed that there were statistical differences in NT-proBNP among the four groups (P ＜ 0.05),but no in NT-proBNP/SCr (P=0.064) and NT-proBNP/SCysC (P=0.320) between the chronic heart failure group and the chronic renal failure with complicated heart failure group.Conclusion NT-proBNP/SCr and NT-proBNP/SCysC can eliminate the effects of renal failure to determine whether chronic renal failure is associated with heart failure.关键词
NT-proBNP/慢性肾衰竭/心力衰竭/SCr/SCysCKey words
NT-proBNP/Chronic renal failure/Heart failure/Serum creatinine/Cystatin C
