中国实用神经疾病杂志2018，Vol.21Issue(24)：2703-2707,5.DOI:10.12083/SYSJ.2018.24.564
多奈哌齐联合尼莫地平片对脑小血管病患者认知功能的影响
Influence of donepezil and nimodipine on cognitive function and life quality of patients with cognitive disorder caused by CSVD
尹刘杰 1李世泽1
作者信息
- 1. 郑州大学附属郑州中心医院,河南 郑州 450000
- 折叠
摘要
Abstract
Objective To investigate the influence of donepezil and nimodipine on cognitive function, life quality of patients with cognitive disorder caused by CSVD.Methods 91 cases with cognitive disorder caused by CSVD in Zhengzhou Central Hospital Affiliated of Zhengzhou University were selected and divided according to random number table.45 cases in control group and was given donepezil, 46 cases in observation group and was given donepezil + nimodipine.The MoCA score and clinic effect of the two groups, record the adverse reactions and QOL of the tow groups were compared.Results 3 months after medicine, MoCA score of observation group was higher than control group, the difference was statistic snigificant (P＜0.05);total efficiency of observation group [89.13％ (41/46) ]was higher than control group [68.89％ (31/45) ], the difference was statistic snigificant (P＜0.05);adverse reaction rate of observation group and control group were 15.22％ (7/46) and 6.67％ (3/45), the difference between the groups was not statistic snigificant (P＞0.05);3 months after medicine, QOL of observation group was higher than control group, the difference was statistic snigificant (P＜0.05).Conclusion Donepezil and nimodipine in treating patients with cognitive disorder caused by CSVD has significant effect and higher safety, it can improve life quality and cognitive function of patients.关键词
脑小血管病/认知功能障碍/盐酸多奈哌齐/尼莫地平片/认知功能/生活质量Key words
CSVD/Cognitive function disorder/Donepezil/nimodipine/Cognitive function/Life quality分类
医药卫生引用本文复制引用
尹刘杰,李世泽..多奈哌齐联合尼莫地平片对脑小血管病患者认知功能的影响[J].中国实用神经疾病杂志,2018,21(24):2703-2707,5.
