中国实用神经疾病杂志2018，Vol.21Issue(24)：2708-2713,6.DOI:10.12083/SYSJ.2018.24.565
丁苯酞注射液对急性缺血性脑卒中患者神经功能及认知的影响
Effect of butylphthalide injection on the nerve function and cognition of acute ischemic stroke patients
摘要
Abstract
Objective To explore the effect of butylphthalide injection on the nerve function and cognition of acute ischemic stroke patients.Methods 106 cases acute ischemic stroke patients treated in First Aid Network Hospital of Zhengzhou City from Feb.2016 to Nov.2017 were selected and divided into control group and study group according to admission order, 53 cases were for each group.Patients in control group were treated with conventional antithromboembolism and other symptomatic support treatments, patients in study group were treated with butylphthalide injection on the basis of control group, and were treated for 2 weeks continuously and followed-up until 3-month after treatment.The improvement of nerve function and cognition in 2 groups were detected and compared.Results he total effective rate of nerve function improvement in study group was 86.79％, which was higher than that 67.92％ in the control group (χ2=5.386, P=0.020);compared with before treatment, the NIHSS scores from 3-day to 3-month after treatment in 2 groups decreased gradually, the MMSE scores and MoCA scores in 2 groups increased gradually (P＜0.01), and the NIHSS scores in study were lower than those in control group 1-month, 3-month after treatment (P＜0.05), the MMSE scores in study group were higher than those in control group 3-day, 7-day, 1-month and 3-month after treatment (P＜0.05 or P＜0.01);the MoCA scores in study group were higher than those in control group 7-day, 1-month and 3-month after treatment (P＜0.05 or P＜0.01).There was no severe adverse reactions occurred during the treatment in 2 groups.Conclusion Butylphthalide injection can improve the nerve function and cognition function of acute ischemic stroke patients effectively, and which has good security.关键词
急性缺血性脑卒中/急性脑梗死/丁苯酞注射液/神经功能/认知Key words
Acute ischemic stroke/Acute cerebral infarction/Butyl phthalate injection/Nerve function/Cognition分类
医药卫生引用本文复制引用
赵琰,李华,王景涛..丁苯酞注射液对急性缺血性脑卒中患者神经功能及认知的影响[J].中国实用神经疾病杂志,2018,21(24):2708-2713,6.基金项目
河南省中医药科学研究专项(编号:2017ZY2134) （编号:2017ZY2134）
