南京大学学报（自然科学版）2019，Vol.55Issue(3)：511-518,8.DOI:10.13232/j.cnki.jnju.201 9.03.019
姜黄素固体分散体的制备及体外评价
Preparation and in vitro evaluation of curcumin solid dispersions
摘要
Abstract
In this study,mixed carriers were used to prepare a solid dispersion of curcumin(CUR)to improve the solubility and dissolution of CUR.The solid dispersions were prepared by solvent method.Taking the in vitro dissolution and saturation solubility as evaluation indicators,combined with Fourier transform infrared spectroscopy (FTIR)and differential scanning calorimetry analysis(DSC),the single-factor test was used to select carrier types, single carrier or mixed carriers,and drug loading for optimizing prescriptions.The final prescription was to use Eudragit? EPO(EPO)and hydroxypropyl methyl cellulose(HPMC)as mixed carriers and the weight ratio of CUR, EPO and HPMC was 1∶2∶2.The CUR was dispersed in the carrier in an amorphous state,and the CUR formed stronger molecular interactions with carriers.The dissolution rate of CUR can be more than 90% in 15 minutes,and the saturation solubility was 9.7 times in the bulk drug.The results indicate that the ternary solid dispersion can greatly improve the solubility and dissolution of CUR,which provides efficient experimental reference for the study of CUR preparations.关键词
姜黄素/固体分散体/混合载体/饱和溶解度/体外溶出度Key words
curcumin/solid dispersion/mixed carrier/saturation solubility/in vitro dissolution分类
医药卫生引用本文复制引用
张心怡,徐艳,狄留庆,樊文玲,李磊..姜黄素固体分散体的制备及体外评价[J].南京大学学报（自然科学版）,2019,55(3):511-518,8.基金项目
国家自然科学基金(30801552,81274095),江苏省研究生科研与实践创新计划(KYCX18_1629),江苏省中药资源产业化过程协同创新中心第三批立项重点项目(ZDXM-3 - 10),第 55 批博士后课题(021062001001 ),江苏省自然科学基金(BK20161403) （30801552,81274095）
