南京医科大学学报（自然科学版）2019，Vol.39Issue(4)：614-618,5.DOI:10.7655/NYDXBNS20190430
SPDEF在气道上皮杯状细胞化生中的作用
Role of SPDEF in the regulation of goblet cell metaplasia of airway epithelium
摘要
Abstract
The SAM pointed domain containing ETS transcription factor (SPDEF) is an important member of the E26 transformation-specific transcription factor family. SPDEF is initially identified in prostatic epithelium and considered to be involved in prostate development and prostate cancer progression. However, recent studies revealed that SPDEF is also expressed in the respiratory system.It is pretty crucial for the differentiation of airway epithelium, especially for the proliferation and metaplasia of goblet cells. Due to the importance of goblet cells in respiratory health, extended understanding of SPDEF function not only helps us to illuminate the mechanism of abnormal mucus secretion but also open new perspectives for the management of these related diseases. This review mainly focuses on the recent data which studied the role of SPDEF in goblet cell control, highlighting a novel profile of SPDEF as a new target in mucus secretion moderation.关键词
杯状细胞/SPDEF/化生/黏蛋白/异常分泌Key words
goblet cell/SPDEF/metaplasia/mucin/abnormal secretion分类
医药卫生引用本文复制引用
仲秀华,曾晓宁..SPDEF在气道上皮杯状细胞化生中的作用[J].南京医科大学学报（自然科学版）,2019,39(4):614-618,5.基金项目
江苏省青年医学人才项目(QNRC2016599) （QNRC2016599）
