山西医科大学学报2019，Vol.50Issue(4)：461-463,3.DOI:10.13753/j.issn.1007-6611.2019.04.015
庆大霉素联合阿奇霉素抗淋球菌的体外研究
In vitro study on effect of gentamicin and azithromycin against Neisseria gonorrhoeae
摘要
Abstract
Objective To investigate the combined effect of gentamicin with azithromycin against Neisseria gonorrhoeae (NG) in vitro.Methods A total of 27 strains of Neisseria gonorrhoeae (NG) were collected from the sexually transmitted disease (STD) clinic of the Second Hospital of Shanxi Medical University from August 2017 to January 2018. The agar dilution method was used to determine the minimum inhibitory concentrations (MICs) of gentamicin and azithromycin against NG isolates. The agar checkerboard dilution method was used to determine the MICs of gentamicin and azithromycin against NG under combined action. Fractional inhibitory concentration index (FICI) was calculated to evaluate the in vitro combined effect of gentamicin and azithromycin against NG isolates. Results The mean MICs of gentamicin and azithromycin were 4. 444 mg/L (4. 000-8. 000 mg/L) and 0. 149 mg/L (0. 060-0. 500 mg/L), respectively. The FICI ranged from 0. 75 to 4. 00, and gentamicin and azithromycin showed an additive effect against the above NG isolates.Conclusion Gentamicin and azithromycin show an additive effect against NG in vitro, so they can be used to resist Neisseria gonorrhoeae under combined action.关键词
淋球菌/庆大霉素/阿奇霉素/联合作用Key words
Neisseria gonorrhoeae/gentamicin/azithromycin/combined action分类
医药卫生引用本文复制引用
董森林,吴丹,王艳青..庆大霉素联合阿奇霉素抗淋球菌的体外研究[J].山西医科大学学报,2019,50(4):461-463,3.基金项目
山西省卫生和计划生育委员会科研课题(2017061) （2017061）
