外科理论与实践2019，Vol.24Issue(2)：149-154,6.DOI:10.16139/j.1007-9610.2019.02.013
唾液肿瘤标志物诊断胰腺癌的研究
Study on salivary tumor markers in diagnosis of pancreatic cancer
摘要
Abstract
Objective To analyze salivary tumor markers in diagnosis and evaluation of pancreatic cancer. Methods Twenty-six patients with pancreatic cancer, 9 patients with benign pancreatic tumor and 16 healthy controls were involved.We compared the concentrations of salivary tumor markers including AFP, CEA, CA125, CA19-9, CA724 and CA242 in three groups to find the tumor marker to diagnose pancreatic cancer and the biomarker associated with the patients of local advanced pancreatic cancer. The tumor marker associated with survival of pancreatic cancer was also studied. Results Salivary AFP, CEA, CA125 and CA724 in the patients with pancreatic cancer were higher when compared those in patients with benign pancreatic tumor and in healthy controls. The difference of salivary tumor markers was present significantly between pancreatic cancer group and control group (P＜0.05). Salivary CEA and CA125 to diagnose pancreatic cancer had area under curve 0.91 and 0.94, respectively. Both tumor markers got same sensitivity 92.31％ and same specificity 84.62％. Salivary CEA and CA125 were associated with the patients of survival less half year and with the patients of locally advanced pancreatic cancer significantly (P ＜0.05). Conclusions The results showed that salivary tumor markers CEA and CA125 could be used in diagnosis of pancreatic cancer at some extent and further study is needed.关键词
胰腺癌/肿瘤标志物/唾液/诊断Key words
Pancreatic cancer/Tumor marker/Saliva/Diagnosis分类
医药卫生引用本文复制引用
赵治锋,彭承宏,谢荣理,沈东杰,张俊,许志伟,程东峰,费健,邓侠兴,沈柏用..唾液肿瘤标志物诊断胰腺癌的研究[J].外科理论与实践,2019,24(2):149-154,6.基金项目
国家自然科学基金(81670581) （81670581）
