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Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking

Suganya Murugesu Zalikha Ibrahim Qamar Uddin Ahmed Bisha Fathamah Uzir Nik Idris Nik Yusoff Vikneswari Perumal Faridah Abas Khozirah Shaari Alfi Khatib

药物分析学报（英文）2019，Vol.9Issue(2)：91-99,9.
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药物分析学报（英文）2019，Vol.9Issue(2)：91-99,9.

Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking

Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking

Suganya Murugesu 1Zalikha Ibrahim 1Qamar Uddin Ahmed 1Bisha Fathamah Uzir 1Nik Idris Nik Yusoff 1Vikneswari Perumal 2Faridah Abas 3Khozirah Shaari 3Alfi Khatib1

作者信息

  • 1. Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, 25200 Kuantan, Pahang Darul Makmur, Malaysia
  • 2. Department of Pharmaceutical Technology, Faculty Pharmacy & Health Sciences, Universiti Kuala Lumpur, Royal College of Medicine Perak, 30450 Ipoh, Perak Darul Ridzuan, Malaysia
  • 3. Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia
  • 折叠

摘要

关键词

Clinacanthus nutans/LC-MS-QTOF/Metabolomics/α-Glucosidase inhibitors/Diabetes/Molecular docking

Key words

Clinacanthus nutans/LC-MS-QTOF/Metabolomics/α-Glucosidase inhibitors/Diabetes/Molecular docking

引用本文复制引用

Suganya Murugesu,Zalikha Ibrahim,Qamar Uddin Ahmed,Bisha Fathamah Uzir,Nik Idris Nik Yusoff,Vikneswari Perumal,Faridah Abas,Khozirah Shaari,Alfi Khatib..Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking[J].药物分析学报（英文）,2019,9(2):91-99,9.

基金项目

The authors wish to thank the Ministry of Agriculture of Ma-laysia for NKEA Research Grant Scheme fund (NRGS SP15-060-0182) and International Islamic University Malaysia for Publication Research Initiative Grant fund (PRIGS18-027-0027). （NRGS SP15-060-0182）

药物分析学报（英文）

OASCI

2095-1779

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