医学信息2019，Vol.32Issue(9)：7-10,4.DOI:10.3969/j.issn.1006-1959.2019.09.003
前列腺癌预后标志的研究
Prognostic Markers of Prostate Cancer
ZHANG Ying 1XIE Jing1
作者信息
- 1. Shanghai Food and Drug Administration Certification and Evaluation Center, Shanghai 200020, China
- 折叠
摘要
Abstract
Objective To explore a genetic marker model that can accurately predict the patient's survival status and improve the success rate of prostate cancer treatment. Methods Using gene expression profiling data and clinical data of prostate cancer patients, the genes with significant correlation with patient survival time were selected as features to construct a prognostic model, and the accuracy of model prediction was verified Results A prognostic marker model consisting of three molecular markers including ENSG00000101844, ENSG00000107077 and ENSG00000117461 was constructed. The prognostic marker model showed better predictive performance and could effectively improve the accuracy of prognosis evaluation of prostate cancer. Conclusion The mRNA prognostic marker model can effectively predict the survival status of patients, and has high prediction accuracy, practicability and stability. It provides possibility for the application of molecular prognosis markers in actual clinical practice, and also selects patients. Provide a more accurate guidance on reasonable treatment options, and provide a theoretical basis for the development of medical device products for detecting the prognosis of prostate cancer.关键词
前列腺癌/预后/标志/基因表达Key words
Prostate cancer/ Prognosis/ Marker/ Gene expression分类
医药卫生引用本文复制引用
ZHANG Ying,XIE Jing..前列腺癌预后标志的研究[J].医学信息,2019,32(9):7-10,4.
