中国实用儿科杂志2019，Vol.34Issue(4)：295-298,4.DOI:10.19538/j.ek2019040611
粪便初次级胆汁酸检测在诊治婴儿胆汁淤积性肝病中的意义
Diagnosis and treatment value of detecting fecal primary and secondary bile acid in infants with infantile cholestatic hepatopathy
摘要
Abstract
Objective To detect the level of fecal primary and secondary bile acids in infants with infantile cholestatic hepatopathy (ICH) and analyze its clinical value. Methods Thirty infants with ICH were enrolled in this study, who were diagnosed with infantile cholestatic hepatopathy. Thirty infants with good health condition were enrolled as the healthy control group. The fecal samples were collected respectively in the preparatory treatment phase and treatment phase from infants with ICH and from the healthy infants. Bile acids were extracted from infants' feces and were quantitatively analyzed by liquid chromatography-mass spectroscopy. Results Among the fecal primary bile acids, the level of cholic acid, chenodeoxycholic and glycochenodeoxycholic acid both in the ICH preparatory treatment group and ICH treatment group was significantly lower than that in the healthy control group (P＜0.016).The level of fecal cholic acid and chenodeoxycholic acid of ICH treatment group was higher than in the ICH preparatory treatment group (P＜0.016).Among the fecal secondary bile acids, the level of lithocholic acid both in the ICH preparatory treatment group and ICH treatment group was significantly lower than that in the healthy control group (P＜0.016), and the level of ursodeoxycholic acid in the ICH preparatory treatment group was lower than that in the ICH treatment group and healthy control group (P＜0.016). Conclusion In infants with ICH, the changes of fecal primary bile acids and fecal secondary bile acids have their own characteristics at the early stage of treatment, which may be caused by the short-term treatment, the prognosis of the disease itself and the changes of intestinal function, including intestinal bacteria. Clinical attention should be paid to these changes.关键词
胆汁淤积性肝病/婴儿/粪便/初级胆汁酸/次级胆汁酸/肠道菌群Key words
cholestatic hepatopathy/infant/feces/primary bile acid/secondary bile acid/intestinal bacteria分类
医药卫生引用本文复制引用
李檬,刘四香,王明英,胡红卫,尹建雯,刘梅,丁臻博,黄永坤..粪便初次级胆汁酸检测在诊治婴儿胆汁淤积性肝病中的意义[J].中国实用儿科杂志,2019,34(4):295-298,4.基金项目
"十二五"云南省特色学科建设项目[云学位(2011)17号] （2011）
云南省卫生内设研究机构项目(2014NS181) （2014NS181）
