中国医科大学学报2019，Vol.48Issue(3)：201-204,4.DOI:10.12007/j.issn.0258-4646.2019.03.002
泛癌症分析DEAH盒解旋酶16的表达及其预后意义
Pan-Cancer Analysis of DEAH-Box Helicase 16 Expression and Prognostic Significance
摘要
Abstract
Objective To investigate the expression and prognostic significance of DEAH-box helicase (DHX16) by pan-cancer analysis. Methods The expression and prognostic significance of DHX16 were analyzed using the UALCAN web-portal. Gene ontology and kyoto encyclopedia of genes and genomes analyses of proteins interacting with DHX16 were performed using DAVID 6.8 functional annotation software. Results DHX16 was highly expressed in bladder urothelial carcinoma, head and neck squamous cell carcinoma, esophageal carcinoma, liver hepatocellular carcinoma, and cholangiocarcinoma (all P ＜ 0.001). Proteins interacting with DHX16 were located mainly in catalytic step 2 spliceosome, nucleoplasm, and cell membrane, and participated in mRNA splicing and processing, binding to poly (A) RNA and nucleic acids, and RNA helicase activity. Spliceosome, mRNA surveillance, RNA degradation, and transport pathways were implicated. Conclusion The high expression of DHX16 is helpful for the prognosis of bladder urothelial carcinoma prognosis, and unfavorable for prognoses of adrenocortical carcinoma, sarcoma, brain lower grade glioma, liver hepatocellular carcinoma, and acute myeloid leukemia. Thus, DHX16 may have value as a prognostic marker.关键词
泛癌症分析/DEAH盒解旋酶16/预后Key words
pan-cancer analysis/DEAH-box helicase/prognosis分类
医药卫生引用本文复制引用
胡明,张淑红,陈跟林,凌存宝,樊伟平,孙海燕,刘爽,张虎..泛癌症分析DEAH盒解旋酶16的表达及其预后意义[J].中国医科大学学报,2019,48(3):201-204,4.基金项目
国家自然科学基金(31471312) （31471312）
江苏医药职业学院科技创新团队建设计划(20188104) （20188104）
江苏省"青蓝工程"项目(2016) （2016）
