中国医科大学学报2019，Vol.48Issue(3)：205-209,215,6.DOI:10.12007/j.issn.0258-4646.2019.03.003
伽马刀联合化疗对局部淋巴结转移性食管癌患者的临床疗效及免疫功能的影响
Effect of Gamma Knife Coupled with Conventional Chemotherapy on the Clinical Efficacy and Immune Function in Patients with Esophageal Carcinoma Complicated by Loco-Regional Lymph Node Metastasis
摘要
Abstract
Objective To observe patients with esophageal squamous cell carcinoma [ESCC, without distant lymph node metastasis (LM) ], who had local LM after radiotherapy and therefore were treated with gamma knife combined with conventional chemotherapy (5-fluorouracil +cisplatin); to evaluate the clinical efficacy in these patients after treatment; and to record adverse reactions. Methods A total of 120 patients with ESCC who underwent radical radiotherapy (with local LM thereafter) without distant LM were randomly divided into control (n = 60; 55 completed the procedure successfully) and observation (n = 60; 50 completed the procedure successfully) groups. The control group was treated with gamma knife, whereas the observation group was given chemotherapy (5-fluorouracil and cisplatin) in addition to the basic gamma knife for 4 courses of treatment. The clinical efficacy of the two groups was compared at the end of treatment, followed by detection of immunological indicators (cellular and humoral immunity) and recording of adverse reactions. Results After treatment, the short-term clinical efficacy in the observation group was found to be better than that in the control group but held no statistical significance (P＞ 0.05). However, the long-term clinical efficacy was significantly enhanced in the observation group than in the control group (P ＜ 0.05). After treatment, the immunological indicators (cellular and humoral immunity) of the two groups were substantially improved post treatment (P ＜ 0.05), exhibiting remarkable enhancement in the observation group compared with the control group (P ＜0.05). Remission rate of the clinical symptoms did not vary significantly between the two groups after treatment (P＞ 0.05). Adverse reactions such as leukopenia, decreased platelet count, nausea, and vomiting were observed during the course of treatment for both the groups, lacking any significant difference (P＞ 0.05). Conclusion Gamma knife coupled with chemotherapy (5-fluorouracil + cisplatin) can improve the treatment efficiency in ESCC patients with local LM following radical radiotherapy.关键词
伽马刀/化学治疗/食管癌/临床疗效Key words
gamma knife/chemotherapy/esophageal carcinoma/clinical efficacy分类
医药卫生引用本文复制引用
李雨微,张曙光..伽马刀联合化疗对局部淋巴结转移性食管癌患者的临床疗效及免疫功能的影响[J].中国医科大学学报,2019,48(3):205-209,215,6.基金项目
国家自然科学基金青年科学基金(81201890) （81201890）
辽宁省自然科学基金(LK201614) （LK201614）
