安徽医科大学学报2019，Vol.54Issue(1)：124-130,7.DOI:10.19405/j.cnki.issn1000-1492.2019.01.025
混合磨玻璃结节肺腺癌CT表现与病理对照研究
Comparative analysis of the CT manifestations of mixed ground-glass nodule and the pathological features of lung adenocarcinomas
摘要
Abstract
Objective To investigate the relationship between CT manifestations, and features of the solid components of mixed ground-glass nodule (m GGN) and the pathological classification of adenocarcinoma in situ (AIS), microinvasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC). Methods CT data of 105 cases (with111 nodules) confirmed to be lung adenocarcinoma were analyzed retrospectively.Based on the pathological findings, there were 15 AIS cases, 23 MIA cases and 73 IAC cases.Many CT manifestations and features of the solid components from these three groups were analyzed.Receiver operating characteristic (ROC) curves were drawn with one factor analysis of variance as the independent variable and invasive findings as the dependent variable.Results There were significant statistical differences in many CT features among those three pathological groups, including m GGN size, shape, lobulation, pleural tag, bronchus sign, blood vessel change, tumor/lung interface, and the count, shape, lobulation, spiculation of the solid components.The average size/ratio/CT value of the solid components were significantly different (P＜0.05) between AIS and MIA, MIA and IAC, while no significant difference (P＞0.05) between AIS and MIA was observed.The Spearman rank correlation analysis showed positive correlation (P＜0.05) between pathological classification and average m GGN size, average size of the solid components, average ratio of the solid components, and average CT value of the solid components, with coefficient being0.535, 0.544, 0.274 and 0.587, respectively.The ROC curve analysis results between non-invasive (AIS and MIA) and invasive (IAC) groups in terms of, average m GGN size, average size of the solid components, average ratio of the solid components, average CT value of the solid components, were as following:area under curve (AUC):0.815, 0.828, 0.681, 0.856;threshold:16.54 mm, 4.83 mm, 46.76％, -39.66 HU;sensitivity:72.6％, 79.5％, 47.9％, 89％;specificity:84.2％, 73.7％, 86.8％, 76.3％. Conclusion There is a correlation between the CT manifestations of m GGN and pathological classification.The probability of IAS is higher with larger m GGN, higher CT value and ratio of the solid components.关键词
磨玻璃密度/肺肿瘤/腺癌/计算机体层成像Key words
ground-glass nodule/lung neoplasms/adnocarcinoma/computed tomography分类
医药卫生引用本文复制引用
周丽芬,李小虎,张为,张佐阳,刘斌,赵韧..混合磨玻璃结节肺腺癌CT表现与病理对照研究[J].安徽医科大学学报,2019,54(1):124-130,7.基金项目
中国博士后科学基金(编号:2017M612090) （编号:2017M612090）
安徽省高校科学研究重点项目(编号:KJ2018A0197) （编号:KJ2018A0197）
国家自然科学基金(编号:81600286) （编号:81600286）
安徽省级质量工程项目(编号:2015jyxm772) （编号:2015jyxm772）
