安徽医科大学学报2019，Vol.54Issue(1)：139-142,4.DOI:10.19405/j.cnki.issn1000-1492.2019.01.028
散发性结直肠癌微卫星不稳定状态与临床病理特征及预后的关系
Relationship between microsatellite instability and clinicopathological features and prognosis in sporadic colorectal cancer
摘要
Abstract
213 cases of sporadic colorectal cancer were selected.The expression of mismatch repair protein (MMR) was detected by immunohistochemistry, and the microsatellite status was detected by PCR-capillary electrophoresis.Microsatellite instability (MSI) was found in 35 out of 213 cases, accounting for 16％.MSI was related to histological grade, classification, location, lymph node metastasis and staging of tumor.20 cases were randomly selected for PCR-capillary electrophoresis, and 3 cases showed high frequency microsatellite instability (MSI-H).MSI tumors have obvious clinicopathologic features and have better prognosis than MSS patients.关键词
结直肠癌/微卫星不稳定/免疫组化/总生存期Key words
colorectal cancer/microsatellite instability/immunohistochemistry/overall survival分类
医药卫生引用本文复制引用
蒋娜,隋燕霞,蒋依娜,张冠军..散发性结直肠癌微卫星不稳定状态与临床病理特征及预后的关系[J].安徽医科大学学报,2019,54(1):139-142,4.基金项目
陕西省社会发展科技攻关项目(编号:2016SF-174) （编号:2016SF-174）
