北京中医药大学学报2019，Vol.42Issue(1)：58-62,5.DOI:10.3969/j.issn.1006-2157.2019.01.010
线叶金雀花与藏红花水提取物抗疲劳的作用研究
Anti-fatigue effects of aqueous extracts from Xianye Jinquehua and Zanghonghua
摘要
Abstract
Objective To study the anti-fatigue effects of aqueous extracts from Xianye Jinquehua (Rooibos, Aspalathus Linears) and Zanghonghua (Saffron, Crocus sativus L.) through classic behavior test (loaded swimming) and detections of blood lactic acid, liver glycogen and muscle glycogen.Methods At first 32 mice were randomly divided into blank control group, Xianye Jinquehua group and Zanghonghua group, and were orally given corresponding medicinals once a day.The test of loaded swimming was conducted in all groups after 14 d.Then 46 mice were randomly divided into blank control group and low-dose XianyeJinquehua+Zanghonghua group, and were orally given corresponding medicinals once a day.The test of loaded swimming and detection of blood lactic acid were conducted in all groups after 14 d.According to above test results, 100 mice were randomly divided into blank control group, low-dose Xianye Jinquehua+Zanghonghua group, middose Xianye Jinquehua +Zanghonghua group and high-dose Xianye Jinquehua +Zanghonghua group.After oral medication for 14 d, the content of liver glycogen and muscle glycogen was detected.Results The time of loaded swimming was not improved in Xianye Jinquehuagroup and Zanghonghua group, and it was prolonged (P<0.05) and content of blood lactic acid was decreased (P<0.05) in low-dose Xianye Jinquehua+Zanghonghua group.The content of liver glycogen and muscle glycogen was increased in low-dose Xianye Jinquehua+Zanghonghua group, mid-dose Xianye Jinquehua+Zanghonghua group and high-dose Xianye Jinquehua+Zanghonghua group compared with blank control group (P<0.05 or P<0.01).Conclusion The single administration of single Xianye Jinquehua or single Zanghonghua has no anti-fatigue effect, while combination of them has this effect.关键词
线叶金雀花/藏红花/负重游泳/血清乳酸/肝糖原/肌糖原/抗疲劳作用/小鼠Key words
Xianye Jinquehua (Rooibos, Aspalathus Linears)/Zanghonghua (Saffron, Crocus sativus L.)/loaded swimming/blood lactic acid/liver glycogen/muscle glycogen/anti-fatigue effect/mice分类
医药卫生引用本文复制引用
马青,范春兰,唐民科..线叶金雀花与藏红花水提取物抗疲劳的作用研究[J].北京中医药大学学报,2019,42(1):58-62,5.基金项目
国家科技重大专项"重大新药创制"项目(No.2011ZX09201-201-22) （No.2011ZX09201-201-22）
