吉林大学学报（医学版）2019，Vol.45Issue(1)：63-68,6.DOI:10.13481/j.1671-587x.20190112
加味丹参饮对慢性心力衰竭大鼠心脏功能和血清炎性因子IL-6及TNF-α的影响
Effects of Jiawei Danshen Yin on cardiac function and serum inflammatory factors IL-6 and TNF-α in rats with chronic heart failure
摘要
Abstract
Objective:To investigate the effects of Jiawei Danshen Yin on the cardiac function and serum inflammatory factors interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the rats with chronic heart failure, and to elucidate the mechanism of Jiawei Danshen Yin in the treatment of chronic heart failure.Methods:The SD rats were randomly divided into blank control group, heart failure model group, captopril group, and Low, medium, and high doses of Jiawei Danshen Yin groups.The rat models of chronic heart failure were prepared by intraperitoneal injection of adriamycin solution for 4 weeks.The left ventricular ejection fraction (LVEF) of the rats was measured by echocardiography.The heart rate (HR) , cardiac output (CO) , systolic blood pressure (SBP) , carotid artery diastolic pressure (DBP) , left ventricular end diastolic pressure (LVEDP) , left ventricular systolic pressure (LVSP) , left ventricular pressure change maximum increase/decrease rate (±dp/dtmax) and other related hemodynamic parameters were measured by ventilator in each group to assess the rat heart function.The levels of inflammatory cytokines IL-6and TNF-αwere detected by enzyme-linked immunosorbent assay (ELISA) .Results:Compared with blank control group, the LVEF of the rats in model group, captopril groups and low, medium, and high doses of Jiawei Danshen Yin groups were decreased (P＜0.05) .Compared with model group, the LVEF of the rats in captopril group and low, medium, and high doses of Jiawei Danshen Yin groups were increased (P＜0.05) .The HR, SBP, DBP, CO, LVSP, and±dp/dtmaxof the rats in model group were lower than those in blank control group (P＜0.05) , while the LVEDP was increased (P＜0.05) .Compared with model group, the SBP, DBP, CO, LVSP and±dp/dtmax of the rats in captopril group and low, medium, and high doses of Jiawei Danshen Yin groups were increased (P＜0.05) , however the HR and LVEDP were decreased (P＜0.05) .Compared with low dose of Jiawei Danshen Yin group, the CO and±dp/dtmaxof the rats in captopril group and medium and high doses of Jiawei Danshen Yin groups were increased (P＜0.05) and the LVEDP were decreased (P＜0.05) .Compared with blank control group, the levels of serum IL-6and TNF-αof the rats in the other groups were increased (P＜0.05) .The levels of serum IL-6and TNF-αof the rats in captopril group and low, medium, and high doses of Jiawei Danshen Yin groups were lower than those in model group (P＜0.05) .Compared with low dose of Jiawei Danshen Yin group, the levels of serum IL-6and TNF-αof the rats in captopril group and medium and high doses of Jiawei Danshen Yin groups were decreased (P＜0.05) .Compared with blank control group, the indexes of heart and lung in the other groups were all increased (P＜0.05) ;compared with model group, the heart and lung indexes of the rats in captopril group and low, medium, and high doses of Jiawei Danshen Yin groups were decreased (P＜0.05) .Conclusion:Jiawei Danshen Yin can improve the heart function of the rats with heart failure and inhibit the expressions of serum inflammatory cytokines IL-6and TNF-αto some extent.In the common dose range, Jiawei Danshen Yin can maximize the benefit of cardiac function and the serum inflammatory factors in the rats with chronic heart failure.关键词
加味丹参饮/慢性心力衰竭/心脏功能/炎性因子/白细胞介素6/肿瘤坏死因子αKey words
Jiawei Danshen Yin/chronic heart failure/cardiac function/inflammatory factor/interleukin-6/tumor necrosis factor-α分类
医药卫生引用本文复制引用
何琦,史华,丹阳,邵素菊..加味丹参饮对慢性心力衰竭大鼠心脏功能和血清炎性因子IL-6及TNF-α的影响[J].吉林大学学报（医学版）,2019,45(1):63-68,6.基金项目
河南省教育厅科研项目资助课题(182102310108) （182102310108）
