吉林大学学报（医学版）2019，Vol.45Issue(1)：73-76,4.DOI:10.13481/j.1671-587x.20190114
SENP1、SENP2和SENP6蛋白在人恶性胶质瘤组织和细胞中的表达及其意义
Expressions of SENP1, SENP2 and SENP6 proteins in human glioma tissue and cells and their mechanisms
摘要
Abstract
Objective:To observe the expressions of SENP1, SENP2and SENP6proteins in human malignant glioma tissue and cells, and to elucidate the their effects in the development of malignant glioma.Methods:The samples of normal human brain tissue and malignant glioma tissue were obtained and used as normal control group and malignant glioma group, respectively.The Cos7cells and the malignant glioma LN443and U343cells were cultured;the Cos7cells were used as normal cell control group, and the LN443and U343cells as malignant glioma cell group.Western blotting method was used to detect the expression levels of SENP1, SENP2and SENP6proteins in human malignant glioma tissue and cells.Results:In brain tissue, the expression levels of SENP1, SENP2and SENP6proteins in malignant glioma group were higher than those in normal control group (P＜0.05) .Compared with normal cell control group, the expression levels of SENP1, SENP2and SENP6proteins in the LN443and U343cells in malignant glioma cell group were significantly increased (P＜0.05) .Conclusion:SENP1, SENP2and SENP6proteins highly express in the malignant glioma tissue and cells, and they may play an important role in promoting the occurrence of malignant glioma.关键词
SUMO特异性蛋白酶/恶性胶质瘤/LN443细胞/U343细胞Key words
SUMO-special proteases/malignant glioma/LN443 cell/U343 cell分类
医药卫生引用本文复制引用
王东东,张宇,张伟琪,丁振东,于洪泉,齐玲..SENP1、SENP2和SENP6蛋白在人恶性胶质瘤组织和细胞中的表达及其意义[J].吉林大学学报（医学版）,2019,45(1):73-76,4.基金项目
吉林省卫计委科研项目资助课题(20152026) （20152026）
吉林省科技厅科研项目资助课题(20140101114JC,20160101195JC) （20140101114JC,20160101195JC）
吉林省产业创新专项基金资助课题(2016C049-2) （2016C049-2）
吉林省教育厅科研项目资助课题(2016236) （2016236）
