吉林大学学报（医学版）2019，Vol.45Issue(1)：94-99,后插3,7.DOI:10.13481/j.1671-587x.20190118
基础转录激活因子1蛋白在胃癌组织中的表达及其临床意义
Expression of activator of basal transcription 1 in gastric cancer tissue and its clinical significance
摘要
Abstract
Objective:To investigate the expression of activator of basal transcription 1 (ABT1) protein in gastric cancer tissue and its relationships with the clinical parameters and prognosis of gastric cancer patients, and to clarify the role of ABT1in the occurrence and development of gastric cancer.Methods:A total of 100cases of cancer tissue of the gastric cancer patients and 80pairs of adjacent tissue were selected.The expressions of ABT1in cancer tissue and adjacent tissue were detected by immunohistochemistry and the proportion of stained cells and the degree of staining in the immunohistochemistry results were analyzed using semi-quantitative analysis.The relationships between the semi-quantitative analysis results and the clinical parameters of gastric cancer patients were statistically analyzed.Kaplan-Meier method was used to analyze the correlation between the ABT1 protein expression level and the survival of gastric cancer patients.Results:ABT1-positive staining was observed in the nucleus and cytoplasm of gastric cancer tissue and adjacent gastric tissue.The expression level of ABT1in gastric cancer tissue was lower than that in adjacent tissue (P=0.021) .The ABT1protein expression level in gastric cancer tissue was significantly negatively correlated with the pathological grade (r=-0.224, P=0.026) .The Kaplan-Meier analysis results of the survival curve showed that the high expression of ABT1was associated with good prognosis in the gastric cancer patients (HR=1.483, P＜0.01) .The survival rate of gastric cancer patients with high ABT1expression was significantly higher than that of the patients with low ABT1expression (HR=2.411, P=0.0272) .Conclusion:The expression of ABT1in gastric cancer tissue is lower, indicating that ABT1can be used one of the markers of good prognosis of gastric cancer.关键词
基础转录激活因子1/胃肿瘤/免疫组织化学/组织芯片Key words
ABT1/stomach neoplasms/immunohistochemistry/tissue microarray分类
医药卫生引用本文复制引用
穆天驰,刘超,富帅,李启阳,王馨梦,肖建英..基础转录激活因子1蛋白在胃癌组织中的表达及其临床意义[J].吉林大学学报（医学版）,2019,45(1):94-99,后插3,7.基金项目
国家自然科学基金资助课题(81270698,31371173,81401199) （81270698,31371173,81401199）
辽宁省科技厅科技计划项目资助课题(2015020697) （2015020697）
