吉林大学学报（医学版）2019，Vol.45Issue(1)：123-129,7.DOI:10.13481/j.1671-587x.20190123
替格瑞洛和氯吡格雷在老年冠心病患者抗血小板治疗中有效性及安全性的Meta分析
Effectiveness and securities of ticagrelor and clopidogrel in antiplatelet therapy for coronary heart disease in old people:A Meta-analysis
摘要
Abstract
Objective:To explore the curative effects and securities of ticagrelor and clopidogrel in the antiplatelet therapy for coronary heart disease in the aged patients, and to provide a more rational strategy for antiplatelet therapy.Methods:Computer search was performed in Cochrane Central Register of Controlled Trial, Ovid-Medline, EMBase, PubMed, CNKI, Wanfang, VIP and CBM, and the randomized controlled trial (RCT) of ticagrelor and clopidogrel in the treatment of coronary heart disease in the old people were collected.The patients in ticagrelor group were given ticagrelor and other drugs, and the patients in clopidogrel group were given clopidogrel and other drugs.RevMan 5.3software was used to perform Meta-analysis, and the adverse events related to the effectiveness such as the major adverse cardiovascular events (MACE) , myocardial infarction (MI) , stent thrombosis, death, stroke and the adverse events related to safety (bleeding event) were observed.Results:According to inclusion and exclusion criteria, a total of 15RCT were included.The results of Meta-analysis showed that the incidences of MACE (RR=0.59, 95％CI:0.46-0.76, Z=4.08, P＜0.01) , MI (RR=0.48, 95％CI:0.28-0.81, Z=2.74, P=0.006) , stent thrombosis (RR=0.16, 95％CI:0.06-0.48, Z=3.30, P=0.0010) , and death (RR=0.52, 95％CI:0.30-0.89, Z=2.41, P=0.02) in ticagrelor group were decreased compared with clopidogrel group;there was no significant difference in stroke rate (RR=0.76, 95％CI:0.39-1.47, Z=0.81, P=0.42) between two groups, and the incidence of bleeding event in ticagrelor group was increased compared with clopidogrel group (RR=1.57, 95％CI:1.20-2.05, Z=3.28, P=0.001) .Conclusion:For the aged patients with coronary heart disease, ticagrelor is superior to clopidogrel;but the incidence of bleeding is increased.关键词
替格瑞洛/氯吡格雷/老年人/冠心病/Meta分析Key words
ticagrelor/clopidogrel/coronary heart disease/Meta analysis/old people分类
医药卫生引用本文复制引用
邢寻静,秦玲,唐明龙,杨硕,徐国良..替格瑞洛和氯吡格雷在老年冠心病患者抗血小板治疗中有效性及安全性的Meta分析[J].吉林大学学报（医学版）,2019,45(1):123-129,7.基金项目
吉林省人力资源与社会保障厅人才开发基金资助课题(802130001428) （802130001428）
