吉林大学学报（医学版）2019，Vol.45Issue(1)：137-142,6.DOI:10.13481/j.1671-587x.20190125
中国胃癌患者癌组织中IGF-1表达与临床病理参数关联性的Meta分析
Relationships between expression of IGF-1 in cancer tissue of gastric cancer patients and clinicopathological parameters in China:A Meta-analysis
摘要
Abstract
Objective:To investigate the relationships between the expression of insulin-like growth factor-1 (IGF-1) in the gastric cancer tissue and the clinicopathological parameters in the gastric cancer patients in China with Meta-analysis, and to provide the evidence-based medical evidence for the diagnosis and treatment of gastric cancer.Methods:The literatures about the relationships between the positive expression rate of IGF-1and the clinicopathological paramters in the gastric cancer patients were searched comprehensively in PubMed, China National Knowledge Infrastructure, Weipu Chinese Science and Technology Journal Database, Wanfang Database and China Biomedical Literature Database.Review Manager 5.2software was used to conduct Meta analysis on the literatures that met the inclusion criteria.Results:There were 11articles in the literatures were selected, including993cases in gastric cancer group and 601cases in non-tumor gastric mucosal tissue control group.Meta-analysis showed the significant differences in the positive expression rates of IGF-1between gastric cancer group and control group (OR=9.05, 95％CI:6.82-12.01) , poorly differentiated gastric cancer group and moderately-highly differentiated group (OR=1.53, 95％CI:1.14-2.06) , involving full-thickness group and unaffected fullthickness group (OR=0.16, 95％CI:0.09-0.28) , lymph node metastasis group and non-lymph node metastasis group (OR=0.12, 95％CI:0.08-0.17) , TNM stageⅢ-Ⅳgroup and TNM stageⅠ-Ⅱgroup (OR=0.21, 95％CI:0.13-0.33) .Conclusion:The high expression of IGF-1in gastric cancer tissue is closely related to the occurrence, development, invasion and metastasis of tumor in the gastric cancer patients in China.The abnormal expression of IGF-1could be used as a risk factor for carcinogenesis of gastric mucosal cells and a valuable molecular biological marker for early diagnosis and treatment of gastric cancer.关键词
胃肿瘤/胰岛素样生长因子1/临床病理参数/Meta分析Key words
stomach neoplasms/insulin-like growth factor-1/clinicopathological paramter/Meta-analysis分类
医药卫生引用本文复制引用
鲁明月,李静..中国胃癌患者癌组织中IGF-1表达与临床病理参数关联性的Meta分析[J].吉林大学学报（医学版）,2019,45(1):137-142,6.基金项目
辽宁省科技厅自然科学基金资助课题(20170540391) （20170540391）
辽宁省科技厅基金资助课题(2013020126-215) （2013020126-215）
