长春中医药大学学报2019，Vol.35Issue(1)：124-127,4.DOI:10.13463/j.cnki.cczyy.2019.01.037
黄芩苷对复发性流产小鼠的保胎作用及子宫免疫微环境的调节
Effect of Baicalin on Fetal Protection and Regulation of Uterine Immune Micro-environment in Recurrent Spontaneous Abortion Mice
摘要
Abstract
Objective To observe the effect of baicalin on RSA and explore its possible immune mechanism to regulate the maternal-fetal interface immune micro-environment.Methods SPF CBA/J females were randomly assigned to group A, B and C.The abortion rate and embryo absorption rate of each group were compared.The contents of CD4+, CD8+T lymphocytes, IFN-γand IL-4 were detected by immunohistochemistry and ELISA, and statistical analysis was performed.Results The abortion rate and embryo absorptivity of group C were significantly lower than those of group B (P＜0.01).The ratio of CD4+/CD8+T ratio and Th1/Th2 ratio in group C were similar to those in group A, but the difference was significant compared with group B (P＜0.05), the B group showed a higher CD4+/CD8+ratio and a Th1/Th2 ratio (P＜0.01).Conclusion Baicalin can inhibit the development of Th1/Th2balance and promote the development of Th2 type by regulating the immune state mechanism of uterus and maternal fetal interface, which can effectively reduce the ratio of CD4+/CD8+, and can effectively inhibit the occurrence of RSA.关键词
黄芩苷/复发性流产/CD4+T细胞/CD8+T细胞/IFN-γ/IL-4/安胎Key words
baicalin/recurrent spontaneous abortion/CD4+T cells/CD8+T cells/IFN-γ/IL-4/tranquilizing fetus to prevent miscarriage分类
医药卫生引用本文复制引用
杨小颀,马雁南,马晓军,胥冰..黄芩苷对复发性流产小鼠的保胎作用及子宫免疫微环境的调节[J].长春中医药大学学报,2019,35(1):124-127,4.基金项目
陕西省中医管理局项目(13-JC002). （13-JC002）
