长春中医药大学学报2019，Vol.35Issue(1)：197-199,3.DOI:10.13463/j.cnki.cczyy.2019.01.057
结直肠癌及其动物模型的研究进展
Advances in Colorectal Cancer and Animal Models
摘要
Abstract
Colorectal cancer is a common malignant tumor of the digestive tract.The incidence and mortality of colorectal cancer is increasing year by year.Therefore, effective treatment and prevention measures are urgently needed.Animal models play a key role in the pharmacological research of colorectal cancer.Appropriate modeling methods are selected according to the experimental objectives, experimental cycles, experimental techniques and other factors.The animal models of colorectal cancer can be divided into chemical induced model, transplanted tumor model and transgenic model.The characteristics of chemical evoked model in different stages are most similar to that of human colorectal cancer, but the tumor is not easy to metastasize.The transplanted tumor model is easy to operate and has a fast molding speed.It belongs to artificial route and has no early stage of cancer.The genetically modified model is closer to the natural occurrence of cancer in etiology, but its tumorigenesis rate is low and it can not be applied to a large number of experimental studies.关键词
结直肠癌/动物模型/化学诱导/移植性/转基因Key words
colorectal cancer/animal model/chemical induction/transplantability/transgenosis分类
医药卫生引用本文复制引用
李萍,李超英,张大方..结直肠癌及其动物模型的研究进展[J].长春中医药大学学报,2019,35(1):197-199,3.基金项目
吉林省科技创新专项(20170307003YY). （20170307003YY）
