动物营养学报2019，Vol.31Issue(1)：15-23,9.DOI:10.3969/j.issn.1006-267x.2019.01.002
壳寡糖对动物机体免疫和炎症调节作用及其机制的研究进展
Research Progress on Regulatory Effect and Mechanism of Chitooligosaccharides on Immunity and Inflammation in Animals
摘要
Abstract
Chitosan oligosaccharides (COS) is a D-glucosamine oligomer linked by β-1, 4 glucosidic linkages that can be deacetylated and hydrolyzed by exoskeletons of arthropods and insects and chitin in fungal cell walls.COS represents a class of natural polymers that not only have physicochemical properties such as water solubility and low viscosity, but also have good pharmacological effects and safety as well as a variety of beneficial biological activities such as anti-inflammatory, anti-oxidant, immune stimulating, anti-microorganisms, anti-tumor, promote tissue regeneration, enhance drug and DNA transmission and enhance calcium absorption.The mechanism of COS involved in a number of important signaling pathways, including the inhibition of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) and activation of AMP-activated protein kinase (AMPK) .This article summarizes the recent progress of COS on the regulation of immune and inflammation in animal body and its mechanism, and discusses the future research directions.关键词
壳寡糖/生物学活性/免疫增强/炎症反应Key words
chitosan oligosaccharides/biological activities/immune enhancement/inflammatory response分类
农业科技引用本文复制引用
张华,童津津,张肇南,蒋林树..壳寡糖对动物机体免疫和炎症调节作用及其机制的研究进展[J].动物营养学报,2019,31(1):15-23,9.基金项目
国家自然科学基金项目 (31702302) （31702302）
北京市教委科技计划项目 (SQKM201710020011) （SQKM201710020011）
北京农学院青年教师科研基金 （）
北京农学院奶牛营养学北京市重点实验室开放课题 （）
大北农青年教师科研基金 （）
