动物营养学报2019，Vol.31Issue(1)：42-47,6.DOI:10.3969/j.issn.1006-267x.2019.01.005
色氨酸微生物代谢产物的肠道免疫调节作用及其机制
Modulation Effect of Tryptophan Metabolites from Microbiota on Intestinal Immune and Its Mechanism
摘要
Abstract
The intestinal microbiota plays a crucial role in nutrition up-take, component metabolism, as well as intestinal immune modulation.As an essential amino acid, tryptophan and its microbiota metabolites, such as indole and indolic acid derivatives play an important role in the balance between intestinal immune tolerance and intestinal microbiota maintenance.The aryl hydrocarbon receptor (AhR) mediates the modulation of intestinal immune by tryptophan microbiota metabolites (as ligands of AhR) , which is beneficial for immune homeostasis.This article mainly clarified the mechanism of intestinal microbiota metabolites regulating the intestinal immune balance and maintaining intestinal health, which provided a new insight on how tryptophan as a nutritional supplementation to prevent or alleviate intestinal inflammation.关键词
色氨酸及其微生物代谢产物/肠道微生物/肠道免疫/芳香烃受体/白细胞介素-22Key words
tryptophan and its microbial metabolites/intestinal microbiota/intestinal immune/aryl hydrocarbon receptor/interleukin-22分类
化学化工引用本文复制引用
邱月琴,杨雪芬,王丽,蒋宗勇..色氨酸微生物代谢产物的肠道免疫调节作用及其机制[J].动物营养学报,2019,31(1):42-47,6.基金项目
国家重点研发计划 (2018YFD0500400, 2018YFD0501100) （2018YFD0500400, 2018YFD0501100）
广州市科技计划项目 (201607020035) （201607020035）
国家自然科学基金 (31402086) （31402086）
现代农业产业技术体系建设专项资金 (CARS-35) （CARS-35）
