中国耳鼻咽喉头颈外科2019，Vol.26Issue(1)：9-12,4.DOI:10.16066/j.1672-7002.2019.01.003
PLOD2蛋白在喉癌组织中的表达及其与预后的关系
PLOD2 expression and its prognosis in laryngeal cancer
摘要
Abstract
OBJECTIVE To study the relationship of the expression of PLOD2 protein in laryngeal carcinoma and the clinicopathological features of patients. METHODS The expression of PLOD2 in paraffin-embedded specimens of 114 patients with laryngeal carcinoma was detected by immunohistochemistry. The relationship between the expression of PLOD2 and clinicopathological features was analyzed by χ2 t est, s urvival a nalysis b y K aplan-Meier method, and multivariate analysis of Cox proportional hazard model. The fresh frozen specimens of 8 patients randomly selected from the patients were detected by realtime quantitative polymerase chain reaction and Western blotting for the expression of PLOD2 in tumor tissues and adjacent normal tissues. RESULTS PLOD2 protein was associated w ith c linical s tage a nd T s tage(P <0.05). The expression level of PLOD2 protein in laryngeal squamous cell carcinoma was higher than that in adjacent normal tissue(P <0.05). Kaplan-Meier survival analysis showed that low expression of PLOD2 was associated with patient survival rate(χ2=12.484, P <0.001). Multivariate Cox regression analysis showed that PLOD2 protein expression and M stage were independent risk factors for laryngeal cancer growth (P value, both <0.05). CONCLUSION The level of POLD2 protein expression was positively correlated with clinical stage and T stage. PLOD2 protein is an independent risk factor for the growth of laryngeal cancer. The higher the expression of PLOD2 protein, the lower the prognosis of patients. PLOD2 protein expression may play an important role in the growth and prognosis of laryngeal cancer, and may be a new molecular marker for judging the growth and prognosis of laryngeal cancer.关键词
喉肿瘤/免疫组织化学/预后/回归分析Key words
Laryngeal Neoplasms/Immunohistochemistry/Prognosis/Regression Analysis引用本文复制引用
李奕萱,邓敏鑫,李韵娴,卢仲明,盛晓丽,许咪咪,张思毅..PLOD2蛋白在喉癌组织中的表达及其与预后的关系[J].中国耳鼻咽喉头颈外科,2019,26(1):9-12,4.基金项目
广州市科学(技术)研究专项(201607010389) （技术）
