儿科药学杂志2019，Vol.25Issue(5)：35-38,4.DOI:10.13407/j.cnki.jpp.1672-108X.2019.05.013
我院儿科2015-2017年痰培养病原菌分布及耐药性分析
Distribution of Pathogenic Bacteria and Drug Resistance Analysis of Pediatric Sputum Culture in Our Hospital from 2015 to 2017
聂彩霞 1赵启邹 1张剑 1茶志芳 1尹思敏 1杨磊 1邹治木 1廖正辉1
作者信息
- 1. 大理市第一人民医院,云南大理671000
- 折叠
摘要
Abstract
Objective: To investigate the distribution of pathogenic bacteria and drug resistance of pediatric sputum culture in pediatrics of our hospital, so as to provide reference for the rational use of antibiotics in clinic. Methods: Discharged cases of paediatrics in our hospital who underwent sputum culture examination from 2015 to 2017 were screened out, and the isolated pathogens and the drug resistance were analyzed and summarized. Results: A total of 1, 003 strains of pathogenic bacteria (positive rate 25.72％) were detected in 3, 900 specimens, including 351 strains (35.00％) of gram-positive bacteria, 617 strains (61.52％) of gram-negative bacteria, and 35 strains (3.49％) of fungi. The top 5 pathogenic bacteria were Escherichia coli (260 strains, 25.92％), Streptococcus pneumoniae (239 strains, 23.83％), Klebsiella pneumoniae (141 strains, 14.06％), Staphylococcus aureus (107 strains, 10.67％) and Haemophilus influenzae (64 strains, 6.38％). The resistance rate of gram-positive bacteria to erythromycin, clindamycin and penicillin was relatively high. The resistance rate of S. pneumoniae to erythromycin was 97.91％, and the resistance rate of S. aureus to penicillin was 96.33％. The drug resistance rate of gram-negative bacteria to the third and fourth generation cephalosporins, β-lactamines containing enzyme inhibitors, monocyclic β-lactamines, and carbapenems was relatively low, among which the drug resistance rates of E. coli and K. pneumoniae to cefaladine were 13.85％ and 36.62％, respectively. The detection rate of methicillin-resistant S. aureus (MRSA) was 15.89％, and the detection rates of E. coli and K. pneumoniae producing extended-spectrum β-lactamase (ESBLs) were 48.46％ and 51.06％, respectively. Conclusion: The pathogens detected in the sputum culture of pediatric inpatients in our hospital are mainly gram-negative bacteria. Different pathogens have different drug resistance to commonly used antibiotics. Antibiotics can be selected according to the bacterial resistance test in clinic so as to improve the curative effect and reduce the resistance of bacteria.关键词
儿科/痰培养/病原菌分布/耐药性分析Key words
pediatrics/sputum culture/pathogen distribution/drug resistance analysis分类
医药卫生引用本文复制引用
聂彩霞,赵启邹,张剑,茶志芳,尹思敏,杨磊,邹治木,廖正辉..我院儿科2015-2017年痰培养病原菌分布及耐药性分析[J].儿科药学杂志,2019,25(5):35-38,4.
