法医学杂志2018，Vol.34Issue(6)：650-655,6.DOI:10.12116/j.issn.1004-5619.2018.06.016
江苏汉族人群19个常染色体STR基因座基因多态性及遗传距离分析
Analysis of Genetic Polymorphism and Genetic Distance of 19 Autosomal STR Loci in Jiangsu Han Population
摘要
Abstract
Objective To investigate the distribution of alleles in 19 autosomal short tandem repeat (STR) loci in Jiangsu Han population.Methods Goldeneye20A kit was used to detect 9 025 samples.Genetic analysis was performed on typing data of 19 autosomal STR loci, and genetic distance with other 17 populations was analyzed.Results All the 19 autosomal STR loci were consistent with the Hardy-Weinberg equilibrium (P＞0.05), with the heterozygosity 0.616 1-0.916 3, probability of match 0.012 8-0.202 6, discrimination power 0.797 4-0.987 2, probability of paternity exclusion 0.310 8-0.828 8, and polymorphic information content 0.561 7-0.913 6.The cumulative discrimination power and cumulative probability of exclusion were 0.999 999 999 999 999 998 434 1 and 0.999 999 989, respectively.The Jiangsu Han population had close genetic distances with the Han population in Tianjin, Hunan and Jilin, and significant difference with Han population in Aletai region in Xinjiang (P＜0.05).Conclusion The STR allele polymorphism data and population genetic parameters of Jiangsu Han population can provide data support for the forensic application of these STR loci in Jiangsu Han population.关键词
法医遗传学/多态现象,遗传/短串联重复/遗传距离/汉族/江苏Key words
forensic genetics/polymorphism, genetic/short tandem repeat/genetic distance/Han nationality/Jiangsu分类
社会科学引用本文复制引用
潘猛,顾民,周惠英,崔鹤,居晓斌,刘燕婷,叶琴,陈子庆,丁小健,陈奇,周蓉..江苏汉族人群19个常染色体STR基因座基因多态性及遗传距离分析[J].法医学杂志,2018,34(6):650-655,6.基金项目
江苏省卫计委卫生标准研究课题资助项目 (S2017004) （S2017004）
江苏省软科学研究资助项目 (BR2018065) （BR2018065）
