广东医学2019，Vol.40Issue(3)：362-365,4.DOI:10.13820/j.cnki.gdyx.20183621
原发性高血压合并2型糖尿病患者Fibulin-3与肱-踝脉搏波传导速度的相关性
Correlation between Fibulin-3 and the branchial-ankle pulse wave velocity in patients with essential hypertension and type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the correlation between Fibulin-3 and the branchial-ankle pulse wave velocity (baPWV) in patients with essential hypertension and type 2 diabetes mellitus (T2 DM). Methods A total of 55 patients with essential hypertension and T2 DM (case group), 62 patients with essential hypertension (control group) and 35 healthy individuals (normal group) were included. Serum levels of Fibulin-3, hs-CRP, and AngII were measured by enzyme-linked immunosorbent assay, latex immunoturbidimetry, and radio immunoassay methods, respectively. The baPWV was measured by the automatic pulse wave velocity meter. Results The serum level of Fibulin-3 in the case group was significantly lower than those in the control group and the normal group [ (40.92±21.84) ng/mL vs. (52.61±27.24) ng/mL and (68.00±29.62) ng/mL, P＜0.05]. The levels of hs-CRP, AngII and baPWV in the case group were significantly higher than those in the control group and the normal group [ (5.96±2.93) ng/L vs. (2.63±1.92) ng/L and (1.22±0.71) ng/L; (55.28±4.97) ng/L vs. (50.29±5.59) ng/L and (47.39±3.05) ng/L; (1 870.33±371.16) cm/s vs. (1 706.11±361.68) cm/s and (1 535.34±253.83) cm/s; P＜0.05]. Fibulin-3 was significantly negatively correlated with baPWV (r=-0.420, P=0.029), hs-CRP (r=-0.570, P=0.011) and AngII (r=-0.586, P=0.013). Conclusion The degree of arteriosclerosis is higher in patients with essential hypertension and T2 DM. Fibulin-3 is involved in the process of vascular remodeling and closely related to inflammation. Further study of its mechanism may help to delay the arteriosclerosis process and target organ damage.关键词
原发性高血压/2型糖尿病/fibulin-3/肱-踝脉搏波传导速度Key words
essential hypertension/type 2 diabetes mellitus/fibulin-3/baPWV分类
医药卫生引用本文复制引用
张炽明,王卓,李稳磊,喻婵,林忠伟,陈滢宇..原发性高血压合并2型糖尿病患者Fibulin-3与肱-踝脉搏波传导速度的相关性[J].广东医学,2019,40(3):362-365,4.基金项目
广东省自然科学基金资助项目(编号:2015A030313583) （编号:2015A030313583）
广东省中医药局建设中医药强省科研课题(编号:20151269) （编号:20151269）
