广东药科大学学报2019，Vol.35Issue(1)：82-87,6.DOI:10.16809/j.cnki.2096-3653.2018112103
低盐饮食对高果糖所致心肌肥大的保护作用
Protective effect of low salt diet on the myocardial hypertrophy induced by high-fructose
摘要
Abstract
Objective To investigate the effect of low salt diet on the rat myocardial hypertrophy induced by high frustose water (HF). Methods Wister male rats were randomly divided into 5 groups, including the control group, high-salt group (HS), high fructose group (HF), high fructose water with high salt diet group (HFHS) and high fructose water with low salt diet group (HFLS). The changes of heart histological evaluation and expression of Sirius Red and α-SMA in heart tissue were detected in each group. Results Compared to the control group, the ratio of heart and body weight in both HF and HS groups were significantly increased (P<0.01). The myocardial cell area of HF group (0.442 3±0.178 0) μm2 was larger than that of the control group (0.189 9±0.079 06) μm2 (P<0.01). The positive staining areas of Sirius Red of HS group was significantly increased compared with the control group (P<0.01). The expression of α-SMA showed that both HF and HS promoted cardiac fibroblast proliferation. HFLS significantly reversed the above indicators and improved myocardial hypertrophy. Conclusion Low-salt diet improves myocardial hypertrophy and prevents the deposition of extracellular matrix induced by high fructose water and high salt.关键词
心肌肥大/心脏纤维化/限钠/高果糖Key words
myocardial hypertrophy/cardiac fibrosis/sodium-restricted/fructose分类
医药卫生引用本文复制引用
李思奇,邓淑华,谢晶舟,文丽静,苏焕厚,王丽京,郑凌云..低盐饮食对高果糖所致心肌肥大的保护作用[J].广东药科大学学报,2019,35(1):82-87,6.基金项目
国家自然科学基金面上项目(31571178) （31571178）
