广东药科大学学报2019，Vol.35Issue(1)：137-139,3.DOI:10.16809/j.cnki.2096-3653.2018101802
齐拉西酮联合丙戊酸钠治疗双相障碍躁狂发作对血清T3和BDNF的影响
Efficacy of ziprasidone combined with valproate in the treatment of bipolar disorder during manic episode and its effect on serum T3 and BDNF
高永双 1陈贻华 1梁灵君 1胡新伟 1蒋廷云1
作者信息
- 1. 中山市第三人民医院,广东 中山 528451
- 折叠
摘要
Abstract
Objective To investigate the efficacy of ziprasidone combined with valproate in the treatment of bipolar manic episodes and its effect on serum three iodine thyroprodine (T3) and brain derived neurotrophic factor (BDNF). Methods A total of 98 patients with bipolar disorder manic episodes in Zhongshan Third Peopleʼs hospital from February 2016 to May 2018 were selected as the subjects. These patients were randomly divided into olanzapine group (n=49) and ziprasidone group (n=49). The patients in the olanzapine group were administrated with olanzapine combined with sodium valproate, while patients in the ziprasidone group were given ziprasidone combined with sodium valproate. After 8-week treatment, the level of serum T3 and BDNF and mania score were measured. Results After treatment, T3 and BDNF in both groups were higher than those before treatment, and ziprasidone group was higher than olanzapine group (P<0.05). After treatment, the scores of manic symptoms in both groups were lower than those before treatment, and ziprasidone group was lower than olanzapine group (P<0.05). Conclusion Ziprasidone combined with valproate sodium is effective in the treatment of bipolar manic attack, which may improve the levels of serum T3 and BDNF in patients.关键词
齐拉西酮/丙戊酸钠/双相障碍躁狂发作/三碘甲状腺原氨酸/脑源性神经营养因子Key words
ziprasidone/sodium valproate/bipolar disorder mania episodes/three iodine thyroxin/brain-derived neurotrophic factor分类
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高永双,陈贻华,梁灵君,胡新伟,蒋廷云..齐拉西酮联合丙戊酸钠治疗双相障碍躁狂发作对血清T3和BDNF的影响[J].广东药科大学学报,2019,35(1):137-139,3.
