中国妇幼健康研究2019，Vol.30Issue(2)：220-223,4.DOI:10.3969/j.issn.1673-5293.2019.02.020
147例侧脑室增宽胎儿染色体核型分析
Chromosome karyotype analysis of 147 fetuses with ventriculomegaly
熊梦华 1程璐 1郑娇 1徐慧 1唐苗苗 1陈必良 1张建芳1
作者信息
- 1. 空军军医大学第一附属医院妇产科,陕西 西安 710032
- 折叠
摘要
Abstract
Objective To investigate the relationship between fetal lateral ventriculomegaly and abnormal karyotype. Methods The karyotype analysis was performed among 147 fetuses with lateral ventriculomegaly from December 2015 to November 2017 in the First Affiliated Hospital of Fourth Military Medical University, and the relationship between lateral ventriculomegaly and abnormal karyotype was retrospectively analyzed. Results Among the 147 cases of fetal lateral ventriculomegaly revealed by ultrasonic screening, there were 123 cases of mild ventriculomegaly, 14 cases of moderate ventriculomegaly, 10 cases of severe ventriculomegaly, 94 cases of isolated ventriculomegaly, and 53 cases of non isolated ventriculomegaly. In 53 cases of non isolated lateral ventriculomegaly, 20 cases had abnormal cardiovascular system. Karyotype analysis showed that there were 126 normal karyotypes and 21 abnormal karyotypes in 147 cases of fetal lateral ventriculomegaly, including 9 cases of trisomy 21. Conclusion The incidence of chromosomal abnormalities in fetuses with lateral ventriculomegaly is high. The abnormal karyotypes include trisomy 21, trisomy 18, chromosome deletion, and translocation. Therefore, when the ultrasonic screening suggests the broadening of the fetal lateral ventricle, it is necessary to perform karyotype analysis.关键词
超声筛查/侧脑室增宽/羊水细胞/染色体核型分析Key words
ultrasonic screening/lateral ventriculomegaly/amniotic fluid cells/karyotype analysis分类
医药卫生引用本文复制引用
熊梦华,程璐,郑娇,徐慧,唐苗苗,陈必良,张建芳..147例侧脑室增宽胎儿染色体核型分析[J].中国妇幼健康研究,2019,30(2):220-223,4.
