中国妇幼健康研究2019，Vol.30Issue(2)：254-257,4.DOI:10.3969/j.issn.1673-5293.2019.02.029
尿液生物标记物在儿童肾病综合征中的研究进展
Research progress in urinary biomarkers for the diagnosis and treatment of children nephrotic syndrome
摘要
Abstract
Nephrotic syndrome (NS) is a group of clinical syndromes caused by increased glomerular basement permeability for various causes, resulting in the loss of large quantities of protein from the urine. Clinical features are as follows: massive albuminuria, hypoproteinemia, hyperlipidemia and edema, and massive albuminuria and hypoproteinemia are the necessary conditions. According to the etiology, NS can be divided into 3 types: primary, secondary and congenital. PNS accounts for about 90％ of childhood NS. Renal biopsy is still the gold standard for the diagnosis and classification of PNS. Renal biopsy is essentially a invasive examination, and there is a potential risk of complications. Repeated renal biopsy is needed in necessity to monitor the progression of the disease, which makes this examination difficult to accept by children and their parents. In order to better diagnose the disease and guide the clinical treatment, there is an urgent need for a reliable noninvasive biomarker to diagnose the children's PNS accurately. This article reviewed the clinical significance of urinary biomarkers in PNS.关键词
肾病综合征/尿液生物标记物/诊断/治疗Key words
nephrotic syndrome (NS)/urinary biomarkers/diagnosis/treatment分类
医药卫生引用本文复制引用
李博,徐红,高健..尿液生物标记物在儿童肾病综合征中的研究进展[J].中国妇幼健康研究,2019,30(2):254-257,4.基金项目
潍坊市科技发展计划资助项目(201302040) （201302040）
