广西医科大学学报2019，Vol.36Issue(4)：516-519,4.DOI:10.16190/j.cnki.45-1211/r.2019.04.005
山楂叶总黄酮对脊髓损伤大鼠运动功能和炎症反应的影响
Effect of hawthorn leaves flavonoids on motor function and inflammatory response in rats with spinal cord injury
摘要
Abstract
Objective:To investigate the effect of hawthorn leaves flavonoids on motor function and inflammatory reaction in rats with spinal cord injury(SCI).Methods:Thirty SD rats were randomly divided into sham-operated group,SCI group and hawthorn leaves flavonoids low-dose(5mg/kg) ,middle-dose(10mg/ kg) and high-dose(20mg/kg) groups,with 6 rats in each group.Except for the sham-operated group,the rat SCI model was established by Allen's method.The motor function were evaluated by Basso-Beattie-Bresnahan(BBB) score.The levels of interleukin(IL) -1β,IL-10 and tumor necrosis factor(TNF) -αwere detected by enzyme linked immunosorbent assay(ELISA).Results:Compared with sham-operated group, the score of BBB in SCI group was significantly decreased,while the levels of IL-1β,IL-10and TNF-αin spinal cord tissues were increased(P<0.05). The concentrations of IL-1β,IL-10and TNF-αin spinal cord tissues of the three treatment groups decreased with the increase of the dose of hawthorn leaves flavonoids(P<0.05).Conclusion:Hawthorn leaves flavonoids could inhibit inflammatory response and improve motor function in SCI rats.关键词
山楂叶总黄酮/脊髓损伤/炎症反应/炎性因子Key words
hawthorn leaves flavonoids/spinal cord injury/inflammatory reaction/inflammatory factor分类
医药卫生引用本文复制引用
熊殷,付雯雯,邓贵营,李博,张琼,曾高峰..山楂叶总黄酮对脊髓损伤大鼠运动功能和炎症反应的影响[J].广西医科大学学报,2019,36(4):516-519,4.基金项目
国家自然科学基金资助项目(No.8186090310) （No.8186090310）
广西自然科学基金项目(No.2018GXNSFAA281144) （No.2018GXNSFAA281144）
广西科技计划课题资助项目(No.桂科AB18221021) （No.桂科AB18221021）
广西高等学校高水平创新团队及卓越学者计划课题资助 （）
