广西医科大学学报2019，Vol.36Issue(4)：533-537,5.DOI:10.16190/j.cnki.45-1211/r.2019.04.009
缬沙坦对阿霉素所致心肌损伤保护作用的相关机制研究
Protective mechanism of valsartan on myocardial injury induced by doxorubicin
摘要
Abstract
Objective:To investigate the protective effect and mechanism of valsartan(Vat) on myocardial injury induced by doxorubicin(Dox).Methods:Twenty-four Sprague-Dawley rats were randomly divided into 4groups(n=6 per group):control group,Vat group,Dox group(15mg/kg) ,Dox+Vat group(30mg/ kg).After 6 weeks,cTnI and BNP levels were measured by ELISA.Pathological changes of myocardial tissues were observed by hematoxylin-eosin (HE) staining,and apoptotic rate of cardiomyocytes was detected by TUNEL.The expression of AT1Rand AT2Rand Bax/Bcl-2 ratio were analyzed by western blotting.Results:Compared with the control group,the levels of cTnI and BNP in serum,cell apoptotic rate,AT1Rexpression level and Bax/Bcl-2 ratio were increased in the Dox group(P<0.05) , and myocardial fiber arrangement was disordered.The effects of Dox were reversed in the presence of Vat, and the AT2 Rexpression level was significantly elevated in Dox+Vat group(P<0.05).Conclusion:Vat could protect rats against Dox-induced myocardial injury by the up-regulation of AT2Rexpression and the inhibition of cell apoptosis.关键词
缬沙坦/阿霉素/心肌损伤/血管紧张素受体/凋亡Key words
valsartan/doxorubicin/myocardial injury/angiotensinⅡreceptor/apoptosis分类
医药卫生引用本文复制引用
郑博宇,俸艳英,阳志军..缬沙坦对阿霉素所致心肌损伤保护作用的相关机制研究[J].广西医科大学学报,2019,36(4):533-537,5.基金项目
广西自然科学基金资助项目(No.2015GXNSFAA139126) （No.2015GXNSFAA139126）
广西第十七批"十百千人才工程"专项资金 （）
广西医学高层次骨千人才"139"计划培养计划 （）
广西壮族自治区临床重点专科建设项目经费资助 （）
