广西医科大学学报2019，Vol.36Issue(4)：634-638,5.DOI:10.16190/j.cnki.45-1211/r.2019.04.034
环境镉暴露对血管内皮功能障碍的贡献度分析
The contribution of environmental cadmium exposure to vascular endothelial dysfunction
摘要
Abstract
Objective:To explore the contribution of different levels of environmental cadmium (Cd) exposure to vascular endothelial dysfunction.Methods:We recruited 667residents aged 20-80years old in the subordinate administrative village of an abandoned lead-zinc mine and the non-polluted area in an adjacent township in Guangxi.Vascular endothelial function was assessed by brachial artery flow-mediated dilatation (FMD) ,the degree of chronic Cd exposure was reflected by urinary cadmium (UCd).Subjects were divided into three groups of low,medium and high according to the concentration of UCd by sex,logistic regression and dominance analysis were used to analyze the effects of different Cd exposure levels on vascular endothelial dysfunction and its contribution.Results:At levels of low,medium and high of Cd exposure,the contribution of UCd to vascular endothelial dysfunction in men were 1.1％ ,5.5％ ,and 8.6％ ,respectively,in women were 7.1％ ,4.4％ ,and 3.2％ ,respectively.Under different exposure levels,there were no significant difference in the effects of UCd on the risk of vascular endothelial dysfunction(P>0.05).Conclusion:Different Cd exposure levels contribute differently to vascular endothelial dysfunction and there are gender differences,which are increased in men and decreased in women.关键词
镉暴露/血管内皮功能障碍/贡献度/心血管疾病Key words
cadmium exposure/vascular endothelial dysfunction/contribution/cardiovascular disease分类
医药卫生引用本文复制引用
莫秋燕,农青娇,毛宝玉,易艳珊,钟秋安..环境镉暴露对血管内皮功能障碍的贡献度分析[J].广西医科大学学报,2019,36(4):634-638,5.基金项目
国家自然科学基金资助项目(No.81860570 （）
No.81360422) （）
广西自然科学基金资助项目(No.2016GXNSFAA380050 （）
No.2014GXNSFAA118167) （）
