化工进展2019，Vol.38Issue(3)：1501-1508,8.DOI:10.16085/j.issn.1000-6613.2018-1200
聚己内酯/壳聚糖核壳结构纤维引导组织再生膜的制备及表征
Preparation and characterization of a guided tissue regeneration membrane constructed by core-shell polycaprolactone/chitosan fibers
摘要
Abstract
High-performance guided tissue regeneration (GTR) membrane is a key factor for successful GTR treatment. Electrospinning has great potential for construction of a GTR membrane because this technique can prepare fibrous structural membrane similar to extracellular matrix, which is beneficial for cell adhesion and proliferation. In this study, the core-shell nanofibers were prepared by coaxial electrospinning technique with polycaprolactone (PCL) as the core and chitosan (CS) as the shell, and the resulting membrane was crosslinked by vanillin. Furthermore, the morphology, internal structure, chemical composition, mechanical properties and cytocompatibility of the fabricated membrane were characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), X ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), mechanical testing and cell culture experiments. Structure analysis showed a core-shell PCL-CS nanofiber constructed membrane was successfully prepared. The results of mechanical and contact angle test showed that the crosslinked fiber membrane had better water resistance, higher mechanical properties and a tensile strength nearly two times higher than the reported studies. Cell culture results showed that the crosslinked fibrous membrane was a good candidate for MG-63 cell adhesion and proliferation, indicating the fabricated membrane has good cytocompatibility. In general, the fibrous GTR membrane constructed by core-shell PCL-CS nanofibers holds promising application.关键词
聚己内酯/壳聚糖/核-壳结构/纳米纤维/引导组织再生膜Key words
polycaprolactone/chitosan/core-shell structure/nanofiber/guided tissue regeneration membrane分类
化学化工引用本文复制引用
邓丹,李玉宝,黄金会,孙富华,左奕,李吉东,王亚宁..聚己内酯/壳聚糖核壳结构纤维引导组织再生膜的制备及表征[J].化工进展,2019,38(3):1501-1508,8.基金项目
国家重点研发计划(2016YFA0201703/2016YFA021700) （2016YFA0201703/2016YFA021700）
国家自然科学基金(31670965) （31670965）
