化工学报2019，Vol.70Issue(3)：817-829,13.DOI:10.11949/j.issn.0438-1157.20180910
阿奇霉素二水合物在水-有机溶剂中溶解度及三元相图测定
Solubility and ternary phase diagram of azithromycin dihydrate in water-organic solvent
摘要
Abstract
The solubility of azithromycinin water + isopropanol and propanone + water solvent mixtures were measured at temperatures from 293.15 K to 323.15 K by an analytical method. The water activity of transformation at 293.15, 298.15, 303.15 and 308.15 K were measured, and the phase diagram of alcoholazithromycin-water at that temperature was obtained through solubility property. The solubility data were correlated by the modified Apelblat equation, λh equation and van't Hoff equation. The results showed that the solubility of azithromycin dihydrate obviously increased with the increase of temperature and the volume fraction of isopropanol and propanone, and the water activity of transformation increased and the coexist area decreased with the increase of temperature. The modified Apelblat equation was the best choice in the correlation of the solubility data.关键词
阿奇霉素二水合物/溶解度/转晶水活度/Apelblat方程/三元相图Key words
azithromycin dihydrate/solubility/water activity of transformation/Apelblat equation/ternary phase diagram分类
化学化工引用本文复制引用
曹小雪,吉绍长,匡雯婕,廖安平,蓝平,张金彦..阿奇霉素二水合物在水-有机溶剂中溶解度及三元相图测定[J].化工学报,2019,70(3):817-829,13.基金项目
国家自然科学基金项目(21066056) （21066056）
广西自然科学基金项目(2017GXNSFAA198091,2014GXNSFBA118037) （2017GXNSFAA198091,2014GXNSFBA118037）
广西生物多糖分离纯化及改性研究平台建设项目(桂科ZY18076005) （桂科ZY18076005）
广西民族大学相思湖创新团队项目(2016) （2016）
广西民族大学研究生教育创新计划项目(gxunchxzs2017128) （gxunchxzs2017128）
