化工学报2019，Vol.70Issue(3)：1208-1219,12.DOI:10.11949/j.issn.0438-1157.20181012
泡沫相相分离制备多孔聚合物微球连续化工艺
Foam phase preparation of porous poly (methyl methacrylate-co-butyl acrylate) microspheres in continuous process
摘要
Abstract
Porous polymeric mirospheres have been widely used since their characteristics in the structure.However, the reported methods are less efficient, especially no continuous process was reported to prepare porous polymeric microspheres. Therefore, there is a need to develop a time-saving method with high yield for producing porous polymeric microspheres. This paper reports a continuous process to prepare porous polymeric microspheres via the solvent evaporation method in foam phase, being efficient and of high yield. Preparation of porous poly (methyl methacrylate-co-butyl acrylate) [P (MMA-BA) ] microspheres was carried out in a customized continuous reaction device. At a certain stirring rate and reaction temperature, the oil phase and the aqueous phase were pumped continuously into the reactor. Foam phase gradually generated and flowed out from the outlet of the reactor.Porous P (MMA-BA) microspheres were obtained after collecting the bubble phase followed by defoaming, washing, filtration and drying. The average foam flow rate, the microspheres' yield, the average particle size and the pore structure were investigated as a function of the experimental conditions including the feed rate of the oil phase, the reaction temperature, the stirring rate and the concentration of PVA. The results showed that the reaction temperature was 45℃, the stirring rate was 500 r/min, the oil phase solution feed rate was 30 g/min, the PVA concentration was 1.0％ (mass), and the oil phase solution P (MMA-BA)∶ DCM∶ HT is 10∶ 53∶rnicrospheres was up to 92％ and the average particle size is 130 μm. The temperature and the residual amount of the aqueous phase left in the customized continuous reaction device are critical for the foam behavior and the yield of the porous P (MMA-BA) microspheres. This work validates that the customized continuous reaction device is capable to produce porous polymeric microspheres continuously, based on the method to prepare porous polymeric microspheres via solvent evaporation method in foam phase, with improved efficiency and yield. In addition, the method reported in this work is able to use continuously on an industrial scale potentially.关键词
泡沫/聚合物/多孔微球/制备Key words
foam/polymers/porous microspheres/preparation分类
化学化工引用本文复制引用
周强,郝军正,祝琳华,王红,司甜,何艳萍,孙彦琳..泡沫相相分离制备多孔聚合物微球连续化工艺[J].化工学报,2019,70(3):1208-1219,12.基金项目
国家自然科学基金项目(21466016,21577053) （21466016,21577053）
云南省科技厅面上项目(2016FB024) （2016FB024）
