中国实用神经疾病杂志2018，Vol.21Issue(22)：2450-2455,6.DOI:10.12083/SYSJ.2018.22.522
IDH-1在胶质瘤中的表达及相关因素分析
Expression of IDH-1 in glioma and analysis of related factors
摘要
Abstract
Objective To study the expression and correlation analysis of IDH-1 in glioma.Methods A total of 92 glioma specimens diagnosed by pathology were collected from the Fifth Affiliated Hospital of Zhengzhou University from January 2015 to May2017. They were divided into two groups according to pathological grade: 60 cases of low-level group (I/Ⅱ). There were 32 patients in the high-grade group (Ⅲ/Ⅳ), including 44 cases of astrocytoma, 24 cases of oligodendroglioma, 12 cases of astrocyte-oligodendroglioma, and 12 cases of glioblastoma. There were 44 males and 48 females. There were 35 patients with epilepsy, including 28 in the low-level group and 7 in the high-level group. Take 20 cases of normal brain tissue obtained by " craniotomy" for craniocerebral trauma in the same period as blank control. Results Negatie expression was observed in normal brain tissue (-). In glioma tissues, high expression (+ + +) in high-grade glioma (Ⅲ/Ⅳ) was 62. 5％ (20/32), higher than 26. 7％ (16/60) of high expression (+++) in low grade glioma (I/Ⅱ) (χ2= 11. 251, P = 0. 000 80). In patients with glioma associated with epilepsy, high expression of IDH1 (+ + +) was 7 cases, and high expression of IDH1 was not associated with epilepsy in 24 cases (χ2= 4. 1470, P = 0. 04171). High expression was 50％ (15/30) in adolescents, 23. 08％ (12/52) in middle-aged patients, and 50％ (5/10) in elderly patients (χ2= 7. 224, P = 0. 027). The degree of expression of IDH1 was not correlated with gender (χ2= 0. 093 0, P = 0. 764 00) and pathological type (χ2= 6. 740 0, P = 0. 080 66). Conclusion The expression of glioma IDH1 is correlated with pathological grade, age and whether it is associated with epilepsy.关键词
胶质瘤/异柠檬酸脱氢酶/免疫组化/癫痫/病理分级Key words
Glioma/Isocitrate dehydrogenase/Immunohistochemistry/Epilepsy/Pathological grading分类
医药卫生引用本文复制引用
王修成,王新军,曾凡涛..IDH-1在胶质瘤中的表达及相关因素分析[J].中国实用神经疾病杂志,2018,21(22):2450-2455,6.基金项目
郑州市科技攻关项目 (编号:20150390) （编号:20150390）
