摘要
Abstract
Objective To observe and explore the changes of interleukin-6 (IL-6), high sensitive C-reactive protein (hsCRP), procalcitonin (PCT), lactate dehydrogenase (LDH), adenosine deaminase (ADA), cholinesterase (CHE), glutamic oxalacetic transaminase (AST/GOT) in cerebrospinal fluid of adult intracranial infectious diseases. Methods A total of 120 patients admitted to the Second Affiliated Hospital of Zhengzhou University from January 2015 to June 2018 were enrolled. Group A was 30 patients with suppurative meningitis, group B was 28 patients with viral meningitis, group C was 22 patients with tuberculous meningitis, and group D was 40 patients without intracranial infection. All patients were examined for PCT, hs-CRP, ADA, IL-6, LDH, CHE, and AST levels, and the differences between the four groups were compared. Results The levels of PCT, hs-CRP and ADA in the cerebrospinal fluid of group A were significantly higher than those of group D, and the difference was significant (P ＜ 0. 05). There was no significant difference in PCT, hs-CRP and ADA levels between the group B and group D (P＞ 0. 05). The cerebrospinal fluid ADA level in the group C was significantly higher than that in the group D, the difference was significant (P＜ 0. 05); the PCT and hs-CRP levels were no significant difference between the group C and group D (P＞ 0. 05). The levels of IL-6, LDH, CHE and AST in the A, B and C groups were significantly higher than those in the group D, and the difference was significant (P＜ 0. 05). Conclusion The levels of PCT, hs-CRP, ADA, IL-6, LDH, CHE, and AST in cerebrospinal fluid of patients with adult suppurative meningitis are significantly increased, and have high early diagnostic value for patients with purulent meningitis; ADA can be used as a differential diagnosis of tuberculosis meningitis.关键词
成人颅内感染性疾病/脑脊液/降钙素原/超敏C反应蛋白/腺苷脱氨酶/白介素6/乳酸脱氢酶/胆碱酯酶Key words
Adult intracranial infectious diseases/Cerebrospinal fluid/Procalcitonin/Hypersensitive C-reactive protein/Adenosine deaminase/Interleukin-6/Lactate dehydrogenase/Cholinesterase分类
医药卫生
