摘要
Abstract
Objective To investigate the effect of serum level of Angpls 2 on the stability of carotid atherosclerotic plaques in patients with acute cerebral infarction. Methods 191 cases of patients wieh newly diagnosed acute cerebral infarction were selected from March 2014 to April 2017 in the Fifth Affiliated Hospital of Zhengzhou University. According to carotid ultrasonography results, the patients were divided into stable plaque group (n = 65), unstable plaque group (n = 69) and no plaque group (n = 65). In the same period, 45 healthy subjects were selected as the control group. The clinical data was collected. The serum level of Angptl 2 was measured by enzyme-linked immunosorbent assay (ELISA). Results The serum level of Angptl 2 in patients with acute cerebral infarction was (3. 74 ± 0. 97) ng/mL, and the serum level of Angptl 2 in the control group was (1. 14± 0. 17) ng/mL, the difference was statistically significant (t = 17. 871, P = 0. 000). The TC, LDL-C, hs-CRP and Angptl 2 in the unstable plaque group were higher than those in the stable plaque group and the no plaque group, while the HDLC was lower than the stable plaque group and the no plaque group, and the Angptl 2 in the stable plaque group was higher than the no plaque group, the difference were statistically significant (P ＜ 0. 05). Pearson correlation analysis showed that the serum level of Angptl 2 in patients with acute cerebral infarction was positively correlated with LDL-C and hs-CRP (r = 0. 234 and0. 618, P = 0. 001 and 0. 000), while was negatively correlated with HDL-C (r = 0. 183, P = 0. 011). Multivariate logistic regression analysis showed that hs-CRP and serum level of Angptl 2 were independent risk factors for the stability of carotid atherosclerotic plaques (P＜ 0. 05). ROC curve analysis showed that the area under the curve for the serum level of Angptl 2 in predicting the stability of carotid atherosclerotic plaque was 0. 900 (95 ％ CI: 0. 848-0. 953), when the serum Angptl 2 was 4. 16 ng/mL, the sensitivity was 79. 7 ％ and the specificity was 87. 7 ％. Conclusion The serum level of Angptl 2 in patients with acute cerebral infarction was increased, and was related with the stability of carotid atherosclerotic plaques. It was an independent risk factor for the stability of carotid atherosclerotic plaques.关键词
急性脑梗死/缺血性脑卒中/Angpls 2/颈动脉粥样硬化/斑块/稳定性Key words
Acute cerebral infarction/Ischemic stroke/Angpls 2/Carotid atherosclerosis/Plaque/Stability分类
医药卫生
