中国实用神经疾病杂志2018，Vol.21Issue(22)：2482-2486,5.DOI:10.12083/SYSJ.2018.22.527
重复经颅磁刺激治疗冠心病合并脑梗死迟发性癫痫患者焦虑抑郁共病
Repetitive transcranial magnetic stimulation for anxiety and depression comorbidity in patients with coronary heart disease and delayed onset epilepsy
张塬坤 1李楠 2董万亮 2贾延劼 3赵友民 1张力俨 1赵国安4
作者信息
- 1. 郑州人民医院, 河南 郑州 450000
- 2. 郑州大学第二附属医院, 河南 郑州 450014
- 3. 郑州大学第一附属医院, 河南 郑州 450052
- 4. 新乡医学院第一附属医院, 河南 新乡 453000
- 折叠
摘要
Abstract
Objective To investigate the clinical efficacy and safety of repeated transcranial magnetic stimulation in the treatment of post-stroke delayed-onset epilepsy with anxiety and depression.Methods Eighty patients with post-stroke delayed epilepsy and anxiety and depression admitted to our hospital from May 2015 to May 2017 were randomly divided into control group (n = 40) and observation group (n = 40).Patients in the control group were treated with routine clinical treatment.The observation group was treated with repeated transcranial magnetic stimulation on the basis of routine treatment, and the clinical efficacy and safety of the two groups were compared.Results Before treatment, there was no significant difference between HAMD score, HAMA score and NIHSS score in both groups (P＞0. 05).After treatment, the two groups of patients The score of each scale was significantly improved, and the improvement effect of the observation group was better than that of the control group (P＜0. 05).After the treatment, the levels of norepinephrine and serotonin in the observation group were (0. 46±0. 08) μmol/L, (36. 82±10. 86) ng/mL and the control group were (0. 31±0. 09) μmol/L and (47. 69±11. 64) ng/mL, respectively, the differences between the two groups were statistically significant (P＜0. 05).The incidence of adverse reactions was significantly lower in the observation group than in the control group (P＜0. 05).Conclusion Post-stroke delayed epilepsy patients with anxiety and depression in patients with common clinical treatment based on repeated transcranial magnetic stimulation therapy can effectively improve the patient's clinical symptoms and improve neurological function, the effect is significant, and higher safety, with more High clinical promotion value.关键词
冠心病/脑梗死/迟发性癫痫/焦虑抑郁共病/重复经颅磁刺激Key words
Coronary heart disease/Stroke/Delayed epilepsy/Anxiety, depression and co-morbidity/Repeated transcranial magnetic stimulation分类
医药卫生引用本文复制引用
张塬坤,李楠,董万亮,贾延劼,赵友民,张力俨,赵国安..重复经颅磁刺激治疗冠心病合并脑梗死迟发性癫痫患者焦虑抑郁共病[J].中国实用神经疾病杂志,2018,21(22):2482-2486,5.
