摘要
Abstract
Objective To observe the effects of different doses of ulinastatin on transforming growth factor β1 (TGF-β1) and prognosis in patients with large area cerebral infarction. Methods Seventy-four patients with large brain cerebral infarction were randomly divided into 3 groups, 22 patients in group A, for intensive care, mannitol dehydration and intracranial pressure, antiplatelet aggregation, craniotomy, nutritional nerve, anti-infection, nutritional support and other comprehensive treatment. In group B, 27 patients were treated with ulinastatin 200, 000 U/d. 25 patients in group C, ulinastatin 400, 000 U/d was added on the basis of this treatment. The difference in TGF-β1 levels before and 10 days and 20 days after treatment, and the mortality rate within 8 weeks of hospitalization were observed. Results There were no significant differences in TGF-β1 levels between the three groups. After treatment for 10 days and 20 days, there was no significant change in TGF-β1 levels in group A, and increased in groups B and C in different degrees, and the group C increased more and the difference was statistically significant. There was no significant difference in mortality among the three groups during hospitalization. Conclusion Ulinastatin can increase the level of TGF-β1 in patients with large-area cerebral infarction, and the degree of improvement is related to the dose, but it can not improve the prognosis.关键词
乌司他丁/大面积脑梗死/转化生长因子β1/颈动脉狭窄/动脉粥样硬化Key words
Ulinastatin/Large area cerebral infarction/Transforming growth factor β1/Carotid stenosis/Atherosclerosis分类
医药卫生
