中国实用神经疾病杂志2018，Vol.21Issue(22)：2518-2522,5.DOI:10.12083/SYSJ.2018.22.533
颈动脉粥样硬化患者转化生长因子β1和基质金属蛋白酶9超敏C反应蛋白的相关性
Correlation between transforming growth factor β1, matrix metalloproteinase-9 and hypersensitive C-reactive protein in patients with carotid atherosclerosis
毛中臣 1苏建 2付志新 1陈卡佳1
作者信息
- 1. 开封市中心医院, 河南 开封 475000
- 2. 郑州市第二人民医院, 河南 郑州 450000
- 折叠
摘要
Abstract
Objective To observe the relationship of transforming growth factor β1 (TGF-β1) and matrix metalloproteinases (MMP-9), hypersensitive C-reactive protein in patients with carotid arterosclerosis (CAS). Methods The subjects who underwent physical examination were CAS patients aged 50-70 years.The CAS diagnostic method is to examine the intima-media thickness (IMT) of bilateral carotid intima using color Doppler ultrasound.The IMT＞1. 1 mm is CAS.The stability of the plaque was expressed by MMP-9.All patients underwent high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and oxidized low-density lipoprotein (ox-LDL), glycerin trilaurate (TG), MMP-9, hs CRP and TGF-β1 were detected.The correlation between TGF-β1 and MMP-9, hs CRP was observed.Results TGF-β1 was negatively correlated with MMP-9 and hs CRP.Conclusion TGF-β1 has a protective effect on the CAS process.关键词
颈动脉粥样硬化/内膜中层厚度/颈动脉粥样硬化斑块/转化生长因子β1/基质金属蛋白酶9Key words
Carotid atherosclerosis/Intima-media thickness/Carotid atherosclerotic plaque/Transforming growth factor β1/Matrix metalloproteinase 9分类
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毛中臣,苏建,付志新,陈卡佳..颈动脉粥样硬化患者转化生长因子β1和基质金属蛋白酶9超敏C反应蛋白的相关性[J].中国实用神经疾病杂志,2018,21(22):2518-2522,5.
