河南中医2019，Vol.39Issue(4)：508-511,4.DOI:10.16367/j.issn.1003-5028.2019.04.0127
桂枝芍药知母汤加味辨治风寒湿痹型急性痛风性关节炎45例
Forty-Five Cases of Acute Gouty Arthritis with Wind-Cold-Dampness Arthralgia Syndrome Treated with Supplemented Cinnamon Twig and Peony Decoction plus Rhizoma Anemarrhenae
摘要
Abstract
Objective:To observe the clinical curative effect of Supplemented Cinnamon Twig and Peony Decoction plus Rhizoma Anemarrhenae on acute gouty arthritis with wind-cold-dampness arthralgia syndrome.Methods:Ninety patients with acute gouty arthritis were randomly divided into the observation group and the control group, with 45 cases in each group.The control group was treated with celecoxib combined with colchicines, while the observation group was treated with Cinnamon Twig and Peony Decoction plus Rhizoma Anemarrhenae on the basis of the control group.The clinical efficacy, pain relief time, recurrence times during follow-up and the incidence of adverse reactions during treatment were compared between the two groups.The changes of TCM syndromes score before and after the treatment were compared between the two groups.Inflammation-related indexes including white blood cell (WBC), C reactive protein (CRP), interleukin-6 (IL-6), interleukin-8 (IL-8), the levels of erythrocyte sedimentation rate (ESR) and blood urea nitrogen (BUN) before and after the treatment were measured.Results:The effective rate was 95.56％ in the observation group and 82.22％ in the control group.There was a significant difference between the two groups (P<0.05).The pain relief time and the recurrence times of 6 months follow-up in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05).After the treatment, the scores of TCM syndromes in both groups were lower than those before the treatment, and the observation group was lower than the control group, the difference was statistically significant (P<0.05).The levels of WBC, CRP, IL-6, IL-8, ESR and BUA in the two groups after the treatment were lower than those before the treatment in the same group, and those in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group, and there was a significant difference between the two groups (P<0.05).Conclusion:Supplemented Cinnamon Twig and Peony Decoction plus Rhizoma Anemarrhenae has a remarkable efficacy on acute gouty arthritis with wind-cold-dampness arthralgia syndrome, can significantly improve the clinical symptoms and inflammatory state of patients.关键词
急性痛风性关节炎/风寒湿痹证/桂枝芍药知母汤/《伤寒论》/张仲景Key words
acute gouty arthritis/wind-cold-dampness arthralgia syndrome/Cinnamon Twig and Peony Decoction plus Rhizoma Anemarrhenae/Treatise on Cold Damage Diseases/Zhang Zhong-jing分类
医药卫生引用本文复制引用
朱慧敏..桂枝芍药知母汤加味辨治风寒湿痹型急性痛风性关节炎45例[J].河南中医,2019,39(4):508-511,4.基金项目
河南省重点中医学科(专科)学术带头人培养项目专项课题项目(2013ZY03003) （专科）
