河南中医2019，Vol.39Issue(4)：512-515,4.DOI:10.16367/j.issn.1003-5028.2019.04.0128
四逆汤配合常规溶栓药物治疗急性心肌梗死缺血再灌注损伤52例
Fifty-two Cases of Ischemia-Reperfusion Injury in Acute Myocardial Infarction Treated with Frigid Extremities Decoction in Combination with Routine Thrombolytic Drugs
摘要
Abstract
Objective:To observe the clinical curative effect of Frigid Extremities Decoction in combination with routine thrombolytic drugs on ischemia-reperfusion injury in acute myocardial infarction.Methods:A total of 104 patients with acute myocardial infarction were divided into the observation group and the control group according to random number table method, with 52 cases in each group.The patients in the control group were treated with routine thrombolytic drugs immediately after admission, while the ones in the observation group were treated with Modified Frigid Extremities Decoction on the basis of the control group.Then the clinical efficacy, ST-segment depression of electrocardiogram after treatment, coronary artery recanalization, reperfusion arrhythmia and complications within 72 hours after thrombolysis were compared between the two groups.Results:The effective rate was 67.3％ in the control group and 92.3％ in the observation group.There was a significant difference between the two groups (P<0.05).After the treatment, the maximum range of ST segment depression in the observation group was significantly higher than that in the control group, and the time required for the maximum range of ST segment depression in the observation group was significantly lower than that in the control group, and there was statistical significance (P<0.05).The relief rate of chest pain in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P<0.05).There was no significant difference in coronary artery recanalization rate and myocardial enzyme peak advance rate between the two groups (P>0.05).Within 72 hours after thrombolysis, the incidence of ventricular premature contraction, paroxysmal ventricular tachycardia, sinus bradycardia and high atrioventricular block in the observation group was significantly lower than that in the control group (P<0.05).Heart failure, post-infarction angina pectoris, hemorrhage, shock and mortality in the observation group were significantly lower than those in the control group, and all the differences were statistically significant (P<0.05).Conclusion:Frigid Extremities Decoction in combination with routine thrombolytic drugs has a remarkable efficacy on acute myocardial infarction, can significantly reduce the risk of ischemia-reperfusion injury.关键词
急性心肌梗死/缺血再灌注损伤/四逆汤/《伤寒论》/张仲景Key words
acute myocardial infarction/Ischemia reperfusion injury/Frigid Extremities Decoction/Treatise on Cold Damage Diseases/Zhang Zhong-jing分类
医药卫生引用本文复制引用
安静,赵伟..四逆汤配合常规溶栓药物治疗急性心肌梗死缺血再灌注损伤52例[J].河南中医,2019,39(4):512-515,4.基金项目
河南省基础与前沿技术研究项目(092300410231) （092300410231）
