中国当代医药2019，Vol.26Issue(11)：8-11,4.
促性腺激素释放激素类似物联合生长激素治疗特发性中枢性性早熟的临床效果
Clinical effect of Gonadotropin -releasing Hormone Analogues combined with Growth Hormone in the treatment of idiopathic central precocious puberty
摘要
Abstract
Objective To investigate the therapeutic effect of Gonadotropin -releasing Hormone Analogue (GnRHa) combined with Growth Hormone (rhGH) on children with idiopathic central precocious puberty (ICPP) and its influence on their height, estradiol (E2) and luteinizing hormone (LH). Methods A total of 68 cases of ICPP female children admitted to Maternal and Child Health Care Hospital of Dongguan City from January 2015 to June 2017 were selected and divided into the experimental group (35 cases) and the control group (33 cases) according to different medication conditions. The control group was treated with GnRHa, and the experimental group was treated with rhGH on the basis of the control group. The height, predicted adult height (PAH), standard difference of height (HtSDSBA), and the levels of LH, follicle stimulating hormone (FSH) and E2 before and after treatment of the two groups were compared. Results There were no significant differences in height, PAH and HtSDSBA between the two groups before treatment (P>0.05). After treatment, the height, PAH and HtSDSBA of the two groups were higher than those before treatment, which in the experimental group were higher than those in the control group, and the differences were statistically significant (P<0.05). There were no significant differences in the levels of LH, FSH after 60 minutes of GnRHa stimulation test and base E2 between the twol group before treatment (P>0.05). After treatment, the levels of LH, FSH and base E2 in the two groups were higher than those before treatment, and which in the experimental group were higher than those in the control group, with statistically significant differences (P<0.05). There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05). Conclusion GnRHa combined with rhGH can significantly improve the predicted height of ICPP children, the levels of E2 and LH in vivo, and the drug is stable and safe. It can be put into use in children with unsatisfactory predicted adult height.关键词
促性腺激素释放激素类似物/生长激素/性早熟/雌二醇/黄体生成激素Key words
Gonadotropin-releasing Hormone Analogues/Growth Hormone/Precocious puberty/Estradiol/Luteinizing hormone分类
医药卫生引用本文复制引用
钟秀玲,李柳韶,李玉凤,程双喜..促性腺激素释放激素类似物联合生长激素治疗特发性中枢性性早熟的临床效果[J].中国当代医药,2019,26(11):8-11,4.基金项目
广东省东莞市社会科技发展一般项目(2018507150421159) （2018507150421159）
