中国当代医药2019，Vol.26Issue(11)：16-20,254,6.
胃腺癌患者病变组织中PPARγ和PGC-1 表达水平与临床病理特征的关系
Relationship between the expression level of PPARγ and PGC-1 in gastric adenocarcinoma tissues and clinicopathological features
刘义文 1廖春娇 2樊利芳3
作者信息
- 1. 湖北省荆州市第二人民医院肝病二科,湖北 荆州 434000
- 2. 湖北省荆州市第二人民医院检验科,湖北 荆州 430000
- 3. 武汉大学基础医学院病理与病理生理学教研室,湖北 武汉 430071
- 折叠
摘要
Abstract
Objective To detect the expression of PPARγ and PGC-1 of the evolution of gastric adenocarcinoma in different stages, and to explore the role of PPARγ and PGC-1 in the development of gastric cancer and its clinicopathological significance. Methods From January 2011 to September 2016, 135 gastric adenocarcinoma tissue specimens, 52 normal gastric mucosa tissue specimens, 19 cases of chronic atrophic gastritis, 31 cases of intestinal metaplasia and 16 cases of atypical hyperplasia were collected from the Second People' s Hospital of Jingzhou City. The expression of PPARγ and PGC-1 was examined by immunohistochemical method. The difference of positive expression of PPARγ and PGC-1 in normal gastric mucosa, precancerous lesions and gastric adenocarcinoma were analyzed, and the correlation between the expression of PPARγ and PGC-1 and the pathological characteristics of gastric cancer were analyzed. Results The positive expression rates of PPARγ and PGC-1 in the gastric cancer tissues were lower than those in the precancerous lesion tissues and the normal gastric mucosa tissues, and the difference was statistically significant (P<0.05). In 135 cases of gastric adenocarcinoma, the expression of PPARγ was positively correlated with PGC-1 expression (r=0.956, P<0.05). The expression levels of PPARγ and PGC-1 were decreased with the lower ranked differentiation of gastric cancer (P<0.05). The expression levels of PPARγ and PGC-1 were closely associated with the Borrmann type, Lauren classification, the histological differentiation and TNM tumor stage (P<0.05). However, there was no significant association between the expression of PPARγ and PGC-1 and the gender, age and lymph node metastasis (P>0.05). Conclusion The expression levels of PPAR and PGC-1 are closely related to the occurrence and development of gastric cancer. Monitoring the expression levels of PPARγ and PGC-1 may be helpful to predict the development and progression of gastric cancer.关键词
胃腺癌/癌前病变/氧化物酶体增殖物激活受体γ/辅助活化因子1Key words
Gastric adenocarcinoma/Precancerous lesions/PPARγ/PGC-1分类
医药卫生引用本文复制引用
刘义文,廖春娇,樊利芳..胃腺癌患者病变组织中PPARγ和PGC-1 表达水平与临床病理特征的关系[J].中国当代医药,2019,26(11):16-20,254,6.
